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LCAL4–FUS cooperation switches on MMP13 and drives osteolytic bone metastasis in breast cancer
Abstract Patients with advanced breast cancer (BC) often experience bone metastasis, leading to severe skeletal complications and a significant decline in prognosis. However, the molecular mechanisms underlying BC bone metastasis remain largely unexplored. This study identified the long non-coding RNA LCAL4 as specifically upregulated in bone-metastatic BC, where it serves as an independent predictor of poor survival.
Safety and tolerability of astegolimab, an anti-ST2 monoclonal antibody: a narrative review - Respiratory Research
Infections occurred in 15–45% of patients treated with astegolimab and 26–51% of patients treated with placebo, and there was no increase in rates of infections following astegolimab treatment compared with placebo (Table 1) [18, 19, 34, 35]. Importantly, no dose-dependent incidence of infections was observed in ZENYATTA (placebo, n = 65 [51.2%]; astegolimab 70 mg, n = 55 [43.3%]; astegolimab 210 mg, n = 58 [46.0%]; astegolimab 490 mg, n = 55 [45.1%]) [18].
Effects of Difenoconazole and Imidacloprid Seed Coatings on Soil Microbial Community Diversity and Ecological Function
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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