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Irisin in Airway Remodeling in COPD: Regulatory Mechanisms from Epithelial Barrier to Smooth Muscle
Keywords chronic obstructive pulmonary disease irisin muscle–lung crosstalk AMPK signaling airway smooth muscle Get full text access Log in, subscribe or purchase for full access. Reference 1. Pan, M. ∙ Zhou, X. Airway remodeling in chronic obstructive pulmonary disease: characteristics and opportunities Front. Med. 2025; 12 2. Taivassalo, T. ∙ Hussain, S.N.A. Contribution of the Mitochondria to Locomotor Muscle Dysfunction in Patients With COPD CHEST. 2016; 149:1302-1312 3.
LCAL4–FUS cooperation switches on MMP13 and drives osteolytic bone metastasis in breast cancer
Abstract Patients with advanced breast cancer (BC) often experience bone metastasis, leading to severe skeletal complications and a significant decline in prognosis. However, the molecular mechanisms underlying BC bone metastasis remain largely unexplored. This study identified the long non-coding RNA LCAL4 as specifically upregulated in bone-metastatic BC, where it serves as an independent predictor of poor survival.
Shared Decision-Making and Professional Responsibility in High-Risk Endoscopic Retrograde Cholangiopancreatography for a Patient With Ankylosing Spondylitis: A Case-Based Reflection in Medical Ethics and Education
1. Introduction Acute cholangitis secondary to choledocholithiasis is a potentially life-threatening condition that requires timely biliary decompression, most commonly achieved by endoscopic retrograde cholangiopancreatography (ERCP) [1]. However, ERCP can become technically demanding in patients with significant anatomical limitations that interfere with endoscopic access, airway management, or procedural positioning [2].
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