The Journal of Allergy & Clinical Immunology
VerifiedJournal
The Journal of Allergy and Clinical Immunology (JACI) is an open access,[1] medical journal in the field of allergy and immunology. It is one of two official journals of the American Academy of Allergy, Asthma, and Immunology. The journal was established in 1929 as the Journal of Allergy and obtained its current name in 1971. The name change was purportedly related to a change in the attitude among physicians about the breadth of applicability of the term "allergy". The journal has been published under the Mosby imprint since its inception. The current publication is released monthly, while the predecessor publication was released every two months. Source
Actions
Media Outlet details
| Scope | International |
|---|---|
| Language | English |
| Country | United States of America |
Similarweb UVM
|
Request pricing |
Comscore UVM
|
Request pricing |
| Frequency | Monthly |
| Accepts contributed content | Yes |
Recent Articles
Search ArticlesIgG:FcγRIIb signals block effector programs of IgE:FcεRI-activated mast cells but spare survival pathways
Article info Publication history Accepted: March 29, 2023 Received in revised form: March 28, 2023 Received: August 12, 2022 Publication stage In Press Journal Pre-Proof Footnotes All authors declare that they have no relevant conflicts of interest. Funding sources: D.F. Dwyer was supported by National Institutes of Health grant K22 AI146281 and by the Brigham and Womens’ Hospital Department of Medicine Hearst Young Investigator award.
Development of mouse models with restricted HLA-B*57:01 presentation for the study of flucloxacillin-driven T-cell activation and tolerance in liver injury
Article info Publication history Accepted: March 27, 2023 Received in revised form: March 23, 2023 Received: November 4, 2022 Publication stage In Press Journal Pre-Proof Footnotes Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationship that could be constued as potential conflic of interest.
Cohort-driven variant burden analysis and pathogenicity identification in monogenic autoinflammatory disorders
Background Nearly 50 pathogenic genes and hundreds of pathogenic variants have been identified in monogenic autoinflammatory diseases (AIDs). Nonetheless, there are still many genes for which the pathogenic mechanisms are poorly understood, and the pathogenicity of many candidate variants needs to be determined. Objective Monogenic AIDs are a group of rare genetic diseases characterized by inflammation as the phenotype.
Eosinophils promote effector functions of lung ILC2s in allergic airway inflammation in mice
Group 2 innate lymphoid cells (ILC2s) are critical mediators of type 2 respiratory inflammation; releasing IL-5 and IL-13 and promoting the pulmonary eosinophilia associated with allergen provocation. Although ILC2s have been shown to promote eosinophil activities, the role of eosinophils in ILC2 responses is less well defined. We sought to investigate the role of eosinophils in activation of ILC2s in models of allergic asthma and in vitro.
IgE cross-inhibition between Ara h 1 and Ara h 2 is explained by complex formation of both major peanut allergens.
Surprisingly, IgE cross-reactivity between the major peanut allergens Ara h 1, 2 and 3 has been reported despite very low sequence identities. To investigate the unexpected cross-reactivity between peanut major allergens. Cross-contamination of purified natural Ara h 1, 2, 3 and 6 was assessed by SDS-PAGE, Western blotting, LC-MS/MS and sandwich ELISA.
News & Notes
The Practice Management Workshop is designed for allergists at every stage of practice and in every employment setting, and their staff. The 2023 program is in Minneapolis, MN from July 28-30.
Corrigendum
A diagnosis of food allergy adversely affects one's ability to join or remain in the military. Inadequate knowledge or misconceptions of current military-specific standards regarding food allergy and how these apply to enlistment, induction, and retention in the US military can lead potentially to inaccurate counseling because each military service has specific regulations that affect the evaluation and decision-making process.
News beyond our pages
Despite its universality, the molecular mechanisms underlying the aging process remain poorly understood. Liu et al (Cell 2023;186:287-304.e26; https://doi.org/10.1016/j.cell.2022.12.017 ) uncovered a positive feedback loop between the activation of dormant endogenous retroviruses and aging. More specifically, cellular senescence induced the reactivation and accumulation of the endogenous retrovirus HERVK.
The Editors’ Choice
Interpreting duodenal eosinophilia Eosinophils reside within the gastrointestinal tract below the esophagus, including the stomach and small and large intestines. Excessive eosinophil levels, known as eosinophilia, are associated with several diseases.