The Journal of Biological Chemistry

Keywords Included in the list: Parkinson disease PARK7 enzyme catalysis enzyme mechanism hydrolase Not included in the list: DJ-1 oxo-aldehyde prokaryote hydratase catalytic triad Abbreviations AGE (advanced glycation end-product) CEL (carboxyethyl-lysine) CML (carboxymethyl-lysine) DMB (1,2-diamino-4,5-methylenedioxybenzene) cPGA (cyclic 3-phosphoglyceric anhydride) GO (glyoxal) HTA (hemithioacetal) LDH (lactate dehydrogenase) MBP (maltose-binding protein) MG-H1...

Research ArticlesArticles in Press113305Open access Affiliations & Notes 1Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan 2Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 3Integrative Bioinformatics Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina...

Keywords Cardiolipin Tafazzin Lipid saturation Mitochondria Barth syndrome Introduction Cardiolipin (CL) is an anionic phospholipid (PL) synthesized and localized in the inner mitochondrial membrane (IMM), where it accounts for ∼20% of total mitochondrial PL content (1–4). Unlike all other PLs, CL exhibits a dimeric structure consisting of two headgroup phosphates and four acyl chains (5).

Keywords DNA methylation epigenetics patient-derived xenografts PDXs miRNA small RNA-seq non-coding RNAs MIR141 promoter tumor promoter prognosis Abbreviations BlCa (bladder cancer) CIS (carcinoma in situ) CT (computed tomography) EMT (epithelial-to-mesenchymal transition) DCA (decision curve analysis) DFS (disease-free survival) EORTC (European Organisation for Research and Treatment of Cancer) gDNA (genomic DNA) HG (high grade) LG (low grade) MIBC (muscle-invasive bladder cancer) miRNAs...

Keywords myosin powerstroke phosphate force-generation Introduction Myosin Va is a prototypical molecular motor responsible for driving vesicular transport within the actin dense regions of cells (1, 2). It moves processively along an actin filament by transducing the chemical energy of ATP into mechanical work(3, 4), in the form of a powerstroke.

Keywords RNA splicing splicing coordination splicing order exon definition minigene ABBREVIATIONS Bact (activated B complex) bp (base pair) CMV (cytomegalovirus) DRS (direct RNA sequencing) EJC (exon junction complex) LCL (lymphoblastoid cell line) nt (nucleotide) Pol (polymerase) SNP (single nucleotide polymorphism) snRNP (small nuclear ribonucleoprotein) SS (splice site) INTRODUCTION Pre-mRNA splicing is an essential step of mammalian gene expression that is catalyzed by the spliceosome, a...

Research ArticlesArticles in Press113301Open access Affiliations & Notes 1Genome Sciences and Technology Graduate Program, University of Tennessee, Knoxville, TN 37996, USA 2Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA Article Info Publication History: Received December 26, 2025; Revised June 1, 2026; Accepted June 12, 2026; Published online June 27, 2026 DOI: 10.1016/j.jbc.2026.113301 External LinkAlso available on...

Keywords miRNA export RNA binding proteins Extracellular Vesicles Gene expression regulation evolution of miRNA export Intercellular communications Introduction Metazoan cells respond to their environment by rapidly switching the expression of genes that confer fitness for survival under challenging conditions(1). The exchange of genetic material allows recipient or donor cells to gain a selective advantage in combating these challenges (2).

Keywords Phosphofructokinase glycolytic regulation glycolysis ancillary pathways fructose 2,6-bisphosphate glucose metabolism metabolic regulation Abbreviations AT2 (alveolar type 2 cells) AMPK (adenosine monophosphate-activated protein kinase) ACMs (adult ventricular cardiomyocytes) cDNA (complementary DNA) CpG-SNPs (CpG single nucleotide polymorphisms) Fru-2,6-P2 (fructose 2,6-bisphosphate) Fru-6-P (fructose 6-phosphate) HIF (hypoxia-inducible factor) Inr (initiator element) IGF (insulin...

Keywords iron–sulfur protein iron metabolism protein-protein interaction protein complex protein structure molecular modeling protein targeting Abbreviations CIA (cytosolic iron–sulfur cluster assembly) CTC (CIA targeting complex) TCR (targeting complex recognition (motif)) CCN (Cia1-Cia2-Nar1 complex, Species abbreviations) Ct (Chaetomium thermophilum) Sc (Saccharomyces cerevisiae) Hs (Homo sapiens) INTRODUCTION Iron-Sulfur (Fe–S) proteins participate in a wide variety of fundamental...