The Journal of Biological Chemistry
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The Journal of Biological Chemistry is a weekly peer-reviewed scientific journal that was established in 1905. Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in areas of biochemistry and molecular biology. The editors-in-chief are Martha Fedor and Herbert Tabor. All its articles are available free after one year of publication. In press articles are available free on its website immediately after acceptance. Source
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| Scope | International |
|---|---|
| Language | English |
| Country | United States of America |
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| Frequency | Weekly |
| Days Published | N/A |
| Accepts contributed content | Yes |
Recent Articles
Search ArticlesFascin in Dendritic Protrusions is Required for Synaptic Plasticity
Keywords Actin cytoskeleton dendrite synapse dendritic spines actin bundling Introduction Chemical synapses are specialized sites of connection that enable neuronal communication underlying sensorimotor behaviors, learning, memory, and cognition. Synapses are composed of pre- and post-synaptic structures specialized for neurotransmitter release and reception, respectively. These structures are highly plastic, undergoing both functional and structural modifications in response to activity (1-3).
G Protein Coupled Receptor Kinase 3 Regulates CCR7 Signaling, Trafficking, and T Cell Responses to CCL19 and CCL21
Research Article Collection: Pharmacology and signal transductionArticles in Press113466Open access Affiliations & Notes 1Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX, United States of America 2Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, KS, United States of America 3Texas Health Physicians Group, Fort Worth, TX, United States of America 4Department of Anesthesiology and...
Epistasis: just say no!
Introduction Epistasis is when the effect of a mutation changes in different genetic backgrounds. It complicates protein design1,2, is a key factor shaping evolutionary trajectories1,3, and is mined as a source of information for understanding biological architecture4.It has been reported in myriad biochemical features: enzyme activity5–12, binding reactions12–17, metabolic pathways18, stability19–21, condensate formation22, and even chromophore color23.
Syndecan-2 Enhances Invasive Motility in Colon Cancer Cells via a Laminin-332–Integrin α6β1 Axis
Keywords Adhesion Cancer Extracellular matrix Integrin Laminin-332 Syndecan-2 Introduction Syndecans (SDCs) are a family of type I transmembrane heparan sulfate proteoglycans, comprising four members (SDC-1 to -4), that function as cell surface receptors by interacting with a wide array of extracellular ligands through their glycosaminoglycan (GAG) chains (1).
Chromogranin A Mediates Glucocorticoid-Induced Enhancement of Vesicular Dopamine Storage and Secretion in PC12 Cells
Research ArticlesArticles in Press113460Open access Affiliations & Notes 1Departamento de Medicina Física y Farmacología. Facultad de Medicina. Universidad de La Laguna. E-38200 - La Laguna. Tenerife. Spain 2Departamento de Bioquímica, Microbiología, Biología Celular y Genética. Facultad de Ciencias. Universidad de La Laguna. E-38200 - La Laguna. Tenerife.
The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin
Keywords Activin B (ActB) follistatin 288 (Fst288) transforming growth factor beta family (TGF‐β) X‐ray crystallography molecular dynamics simulations (MDS) Abbreviations ActA (Activin A) ActB (activin B) BMP (bone morphogenetic protein) BSA (buried surface area) ECM (extracellular matrix) Fst288 (follistatin 288) FSD1–3 (follistatin domains 1–3) HS (heparan sulfate) HBS (heparin binding sequence) MDS (molecular dynamics simulations) MM-GBSA (Molecular Mechanics-Generalized Born Surface Area)...
Denuded peptidoglycan oligosaccharides enable the biochemical investigation of bacterial cell wall recognition, modification, and degradation
Introduction Bacterial cells are surrounded by a cell wall composed of a peptidoglycan (PG) layer that provides structural support for growth, division, and morphogenesis. These processes rely on PG to counteract the internal osmotic pressure exerted on the cell membrane, allowing bacteria to survive in hypotonic environments (Fig. 1A).
Bat-Derived Antimicrobial Peptide MC-CATH3 Confers Protection Against Bacterial Infections via a Potential Ferroptosis-Like Death Process
KEYWORDS antimicrobial peptide reactive oxygen species antimicrobial mechanism ferroptosis-like death INTRODUCTION The relentless rise of antibiotic-resistant bacteria has become one of the most pressing global health crises. In 2019 alone, antimicrobial resistance (AMR) claimed millions of lives worldwide, exceeding the combined mortality of AIDS and malaria 1.
The integrated stress response kinase GCN2 prevents ZAKα-Dependent inflammatory hyperactivation in macrophages
Research ArticlesArticles in Press113452Open access Affiliations & Notes 1Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology (IB), University of Campinas (UNICAMP), Campinas, Brazil 2Department of Immunoregulation, Max Planck Institute of Biochemistry (MPIB), Max Planck Society (MPG), Martinsried, Germany 3Department of Biochemistry and Tissue Biology, Institute of Biology (IB), University of Campinas (UNICAMP), Campinas, Brazil 4Max Planck Institute of...
Discovery of Novel Druggable Binding Pockets on SARS-CoV-2 PLpro via Fragment Screening and Insights for Structure-Based Inhibitor Design
Research ArticlesArticles in Press113453Open access Affiliations & Notes aNational Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China bUniversity of Chinese Academy of Sciences, Beijing, China cShanghai Normal University, Shanghai, 200234, China Article Info Publication History: Received April 6, 2026; Revised August 6, 2026; Accepted August 8, 2026; Published online August 14, 2026 DOI:...