F. Peter Guengerich on Muck Rack

F. Peter Guengerich

As seen in: The Journal of Biological Chemistry, Nature, ScienceDirect, MDPI, American Chemical Society, Drug Metabolism and Disposition (ASPET), Pharmacological Reviews, ASBMB Today
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with F. Peter

Contact F. Peter, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Interaction of Cytochrome P450 3A4 with Fatty Acid Binding Protein 1 and Relevance to Drug Metabolism

|
By Kevin McCarty, F. Peter Guengerich, Destiny L. D. Proffett
| dx.doi.org
Introduction Click to copy section linkSection link copied! The accurate prediction of human hepatic drug clearance is crucial to the development of safe and efficacious small molecule therapeutics. Central to the process of physiologically based pharmacokinetic (PBPK) modeling is the extrapolation from experimentally determined in vitro drug metabolism parameters to estimate human intrinsic clearance in vivo, i.e., in vitro to in vivo extrapolation (IVIVE).
Open in Who Shared Issue with article?

A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1 - Nature Communications

|
By Galina I. Lepesheva, F. Peter Guengerich
| Nature Verified
Abstract Biosynthesis of all androgens and estrogens from cholesterol requires CYP11A1 and CYP17A1. There is no known pathway in humans or other vertebrates that circumvents CYP17A1 for androgen or estrogen biosynthesis in physiology or disease. However, CYP17A1 inhibition cannot completely inhibit androgen biosynthesis in prostate cancer. Here, we identify a surprising role for CYP51 in androgen biosynthesis that bypasses the requirement for CYP17A1.
Open in Who Shared Issue with article?

Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations

|
By F. Peter Guengerich, Yasuhiro Tateishi, Kevin McCarty, Francis K. Yoshimoto
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Open in Who Shared Issue with article?
See all 59 articles
 •  Privacy  •  Terms  •  Security and Legal  •   •   •   • 

© 2026 Muck Rack

SOC 2® Certified