The Journal of Clinical Investigation

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The Journal of Clinical Investigation is a premier venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Source

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Scope National
Language English
Country United States of America
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Frequency Monthly
Accepts contributed content Yes

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A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated Caspase-1 inhibition

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By Huirong Li, Vincent P Kunze, Takerra Johnson-Stephenson
| The Journal of Clinical Investigation
ResearchCell biologyOphthalmology Open Access | 10.1172/JCI191272 J Clin Invest. https://doi.org/10.1172/JCI191272. Copyright © 2026, Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Heterogeneous degeneration of the retinal pigment epithelium (RPE) leads to irreversible blindness in diseases associated with macular atrophy.
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SARS-CoV-2 infection produces an IL-33-dependent chronic eosinophilic pneumonia and muco-inflammatory airways disease in mice

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By JCI Insight, Padraig Hawkins, Sarah R. Leist
| The Journal of Clinical Investigation
ResearchImmunologyPulmonologyVirology Open Access | 10.1172/jci.insight.203283 JCI Insight. https://doi.org/10.1172/jci.insight.203283. Copyright © 2026, Hawkins et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Post-acute sequelae of SARS-CoV-2 (PASC) occurs in subsets of individuals, including those with pre-existing lung disease.
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PTEN deficiency confers sensitivity to ATR inhibitor-based treatment in high-grade serous ovarian cancer

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By Jie Hao, Bose Kochupurakkal, Timothy B. Branigan
| The Journal of Clinical Investigation
ResearchCell biologyClinical ResearchOncology Open Access | 10.1172/JCI197645 J Clin Invest. https://doi.org/10.1172/JCI197645. Copyright © 2026, Hao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Fate-mapping infiltrating monocytes following experimental myocardial infarction revealsdifferentiation trajectories in the infarcted heart

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By Andrew Koenig, Farid F. Kadyrov, Junedh Amrute
| The Journal of Clinical Investigation
ResearchCardiologyImmunology Open Access | 10.1172/JCI189684 J Clin Invest. https://doi.org/10.1172/JCI189684. Copyright © 2026, Koenig et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Inflammation contributes to the pathogenesis of myocardial infarction and heart failure and represents a viable therapeutic target.
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ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression

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By Xinyi Tu, Xiangyu Zeng, Yaoliang Sun
| The Journal of Clinical Investigation
ResearchCell biologyImmunologyOncology Open Access | 10.1172/JCI192285 J Clin Invest. https://doi.org/10.1172/JCI192285. Copyright © 2026, Tu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Our research uncovers a new role for ATR in responding to extracellular matrix (ECM) stiffness and promoting epithelial-to-mesenchymal transition (EMT) and metastasis.
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CD20 + T follicular helper-like cells drive antigen-specific autoimmunity in bullous pemphigoid

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By Hui Fang, Shengxian Shen, Tianyu Cao
| The Journal of Clinical Investigation
ResearchAutoimmunityDermatology Open Access | 10.1172/JCI197665 J Clin Invest. https://doi.org/10.1172/JCI197665. Copyright © 2026, Fang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract CD20+ T cells are increasingly recognized as drivers of autoimmune and inflammatory diseases.
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Excess muscle plasma membrane leak disrupts extracellular matrix content and shifts macrophage-mediated muscle repair

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By JCI Insight, Gahyun Annie Lee, Alexander J. Fitt
| The Journal of Clinical Investigation
ResearchInflammationMuscle biology Open Access | 10.1172/jci.insight.205137 JCI Insight. https://doi.org/10.1172/jci.insight.205137. Copyright © 2026, Lee et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Plasma membrane repair is critical for tissue integrity, especially for elongated contractile muscle cells.
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Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults

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By TUẤN TRẦN, Tuan Tran, Zonghui Hu, Kassoum Kayentao
| The Journal of Clinical Investigation
Clinical Research and Public HealthClinical ResearchImmunologyInfectious disease Open Access | 10.1172/JCI207559 J Clin Invest. https://doi.org/10.1172/JCI207559. Copyright © 2026, Tran et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Background. CIS43LS is a long-acting mAb that targets the Plasmodium falciparum circumsporozoite protein.
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Extracellular matrix reprogramming by the YAP/TAZ– TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models

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By Marco Jessen, Marie Tollot-Wegner, Anita Cindric Vranesic
| The Journal of Clinical Investigation
ResearchHepatologyOncology Open Access | 10.1172/JCI201579 J Clin Invest. https://doi.org/10.1172/JCI201579. Copyright © 2026, Jessen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract YAP and TAZ, key effectors of the Hippo pathway, are often hyperactivated in cancer, promoting tumor progression and therapy resistance.
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Tumor cell-derived extracellular vesicles foster the immunosuppressive landscape of pancreatic cancer

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By Zainab Hussain Verified, Cláudio Montenegro, Christopher Rovera
| The Journal of Clinical Investigation
ResearchCell biologyGastroenterologyImmunology Open Access | 10.1172/JCI197733 J Clin Invest. https://doi.org/10.1172/JCI197733. Copyright © 2026, Hussain et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Pancreatic cancer remains a devastating disease with limited therapeutic options.
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The Journal of Clinical Investigation Journalists

Drouet, Céline
Neill, Ushma S.
Silver, Daniel