The Journal of Clinical Investigation
Journal
The Journal of Clinical Investigation is a premier venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Source
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| Scope | National |
|---|---|
| Language | English |
| Country | United States of America |
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| Frequency | Monthly |
| Accepts contributed content | Yes |
Recent Articles
Search ArticlesTargeting the PRMT5-Nur77 methylation axis enhances endometrial decidualization capacity and female fertility in preclinical models
ResearchGeneticsReproductive biology Open Access | 10.1172/JCI178862 J Clin Invest. https://doi.org/10.1172/JCI178862. Copyright © 2026, Cao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Defective endometrial decidualization is one major cause of female infertility, yet the underlying mechanisms remain elusive.
Inherited salt retention is associated with increased IL-17 responses and autoimmunity
Research LetterIn-Press PreviewImmunologyNephrology Open Access | 10.1172/jci.insight.206932 Inherited salt retention is associated with increased IL-17 responses and autoimmunity 1Centre for Kidney and Bladder Health, University College London, London, United Kingdom 2UCL Centre for Translational Cardiovascular Imaging, University College London, London, United Kingdom Find articles by Rauf, M.
ITGBL1-MYH9 interaction in hepatic stellate cells acts as a mechano-regulator controlling liver fibrosis in mice
ResearchCell biologyHepatology Open Access | 10.1172/JCI203412 J Clin Invest. https://doi.org/10.1172/JCI203412. Copyright © 2026, Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Hepatic stellate cell (HSC) activation can lead to liver fibrosis, for which there are no effective treatments.
Growth of PIK3CA-driven cerebral cavernous malformations does not require microbiome stimulation
Research LetterIn-Press PreviewNeuroscienceVascular biology Open Access | 10.1172/jci.insight.208733 Growth of PIK3CA-driven cerebral cavernous malformations does not require microbiome stimulation 1Cardiovascular Institute and Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America 2Section of Neurovascular Surgery Department of Neurological Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, United...
Human pericardial macrophages suppress cardiac fibrosis through cystatin C signaling after myocardial infarction
ResearchCardiologyInflammation Open Access | 10.1172/jci.insight.202383 JCI Insight. https://doi.org/10.1172/jci.insight.202383. Copyright © 2026, Fatehi Hassanabad et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract The pericardium plays an important homeostatic function for the neighbouring heart providing both lubricating and structural support.
The risk of nephrotic range proteinuria and kidney failure in primary laminopathies is genotype-specific
Clinical Research and Public HealthGeneticsNephrology Open Access | 10.1172/jci.insight.192062 JCI Insight. https://doi.org/10.1172/jci.insight.192062. Copyright © 2026, Sewerin et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Supplemental material Version history Version 1 (July 16, 2026): In-Press Preview
Epilepsy-associated digenic variants affecting an actin–mitochondria–glutamate pathway promote seizure susceptibility
ResearchDevelopmentGeneticsNeuroscience Open Access | 10.1172/JCI198696 J Clin Invest. https://doi.org/10.1172/JCI198696. Copyright © 2026, Lu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Hypercapnia enhances airway smooth muscle contractility via STIM1-dependent Ca 2+ signaling
ResearchCell biologyMuscle biologyPulmonology Open Access | 10.1172/jci.insight.202475 JCI Insight. https://doi.org/10.1172/jci.insight.202475. Copyright © 2026, Shigemura et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Histone lysine methyltransferases KMT2C and KMT2D join the all-star tumor suppressor team in gastrointestinal cancer
Abstract Members of the type 2 histone lysine methyltransferase family (KMT2s) are key drivers of enhancer activation and are the most mutated group of epigenetic regulators in different cancer types. Within this family, KMT2C and KMT2D have the highest mutational incidence across various cancers. To evaluate their role in gastric cancer, Wang et al. developed a Pten deficiency–driven genetically engineered mouse model with inducible loss of Kmt2c and Kmt2d in gastric epithelial cells.
The bone-cerebrovascular axis: effects of bone aging on neurovascular dysfunction and neurodegeneration
Abstract Beyond serving as a structural organ, the skeleton undergoes continuous remodeling and functions as an endocrine organ by secreting bioactive factors that regulate the physiology of distant tissues. Indeed, the concept of a “bone-vascular axis” has long been recognized, supported by epidemiological evidence linking osteoporosis and low bone mass to increased cardiovascular morbidity and mortality.