With this entry, the Conversations with Giants in Medicine series comes to a close. The JCI is heading in a new direction with its video content, and I too will be heading in a different career direction that makes it hard to continue the series with the same care. As is often noted, “All good things must come to an end.” To watch a supercut of the last question I asked each subject, “What other vocation could have kept you as motivated?” see the JCI website at https://www.jci.org/videos/cgms.