LabRoots

Diagnosing rodent pathogens can be challenging when infections are subclinical, clinical signs are nonspecific, or test results are inconclusive. Join Charles River diagnostic experts for a case-based discussion of real-world investigations involving Corynebacterium muris, Clostridium cuniculi, Salmonella, LCMV, and other unexpected agents.

ALREADY ACCESSED THIS App Note? SIGN IN This application note explores how combining 3D single spheroid models with live-cell analysis can enhance compound screening and drug discovery workflows. Using a library of 880 FDA-approved compounds, researchers evaluated changes in spheroid growth, viability, and morphology over time to gain a more comprehensive understanding of compound activity than traditional endpoint assays can provide.

Did Earth and Mars form the same? This is what a recent study published in Nature Astronomy hopes to address as an international team of researchers investigated the complex processes responsible for the formation and evolution of Earth and Mars, focusing on the similarities and differences. This study has the potential to help scientists better understand the formation of rocky planets and what this could mean in the search for life beyond Earth.

Date: November 10, 2026 Time: 8:00 AM PT, 11:00 AM ET The aim of this presentation is to provide an overview of the experience acquired in the implementation and application of various methodologies, including qPCR, digital PCR, and targeted NGS panels, for the analysis of biomarkers in samples derived from different tumor types, including FFPE tissues, cytological specimens, and liquid biopsies.

Newer blood-thinning medications known as NOACs may be associated with slower cognitive decline among people with both Alzheimer’s disease and atrial fibrillation (AF), reported a new study published in the European Heart Journal. AF is a common heart rhythm disorder that increases the risk of blood clots and stroke. It is often treated with anticoagulants.

What new methods can be developed to improve cancer detection in blood samples? This is what a recent study published in Nanoscale Horizons hopes to address as a team of researchers from Japan investigated a novel technique that could revolutionize cancer detection. This study has the potential to help scientists, medical professionals, and the public better understand new developments in cancer detection and the steps that can be taken to implement them.

A previously unknown tick-borne virus has been discovered in China. This virus can cause fever, gastrointestinal symptoms, fatigue, and low platelet counts, and co-infection with other viruses can lead to more serious complications. The new virus was discovered in relation to a second tick-borne virus that is endemic in Asia. This endemic virus, the Dabie bandavirus (DBV), can cause severe fever with thrombocytopenia syndrome, a hemorrhagic fever disease with a fatality rate of 10 to 30%.

Creating neural cell models that are both biologically relevant and reproducible remains a key challenge in neuroscience research. From maintaining high-quality pluripotent stem cells (PSCs) to directing neural differentiation, achieving appropriate maturation, and measuring functional activity, each stage of the workflow can influence the quality and consistency of the final model.

Bringing a new therapeutic from preclinical development into the clinic requires more than simply transferring existing analytical methods. Clinical studies introduce new logistical, regulatory, and scientific challenges that can impact bioanalytical strategy, assay performance, and ultimately study success. Join Charles River experts as they explore the key considerations for successfully progressing bioanalytical programs into clinical development.

Menopause is a milestone in female biological aging, and a new proteomics study suggests that it accelerates brain aging, inflammatory signaling, and dementia risk as sex hormones decline. A group of US and Canadian scientists set out to identify molecular signatures of menopause in blood samples from 80 pre-, peri-, and postmenopausal women, and validated them in nearly 3,000 additional midlife women.