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1 Introduction Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterized by the progressive degeneration of nigrostriatal dopaminergic neurons and the widespread intracellular aggregation of α-synuclein (α-Syn) (Karikari et al. 2018). Clinically, PD is defined by its hallmark motor symptoms—bradykinesia, resting tremor, muscular rigidity, and postural or gait disturbances.
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