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Abstract Despite studies linking metabolism and cancer, our understanding of the metabolite network that drives metastasis remains incomplete. Through a metabolic RNAi-based screen for cell invasion, we identify alpha-aminoadipate (2-AAA), the intermediate metabolite of aminoadipic semialdehyde synthase (AASS) in the saccharopine pathway, as a common pivotal factor in metastasis of human cancers.
Poster Presentations - Proffered Abstracts Briana B. Rackley, Chang-Soo Seong and Melissa Gilbert-Ross DOI: 10.1158/1557-3125.RAS18-B04 Published May 2020 Abstracts: AACR Special Conference on Targeting RAS-Driven Cancers; December 9-12, 2018; San Diego, CA Abstract Although activating mutations in the GTPase KRAS are oncogenic and implicated in various malignancies, mutations in KRAS alone are inefficient to transform epithelia.
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