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Abstract Triple-negative breast cancer (TNBC) frequently develops chemoresistance, but the mechanisms supporting tumor persistence remain incompletely understood. We integrated single-cell transcriptomic data with clinical cohort analyses to identify genes associated with chemotherapy exposure and prognosis. Malignant epithelial populations enriched after chemotherapy occupied terminal branches of the inferred pseudotime trajectory and exhibited higher stemness scores.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
