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Articles by Michael E. Authement
Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices
Abstract Everyday decisions depend on associations between sensory stimuli, actions, and outcomes. The striatum supports these sensorimotor associations through dopamine-dependent plasticity. Recent work has characterized a local striatal microcircuit in which cholinergic interneurons (CINs) modulate dopamine release via activation of nicotinic receptors on dopamine axons. Here, we show that visual stimuli evoke dopamine in the dorsomedial striatum partly through this cholinergic mechanism.
A synaptic mechanism for encoding the learned value of action-derived safety
Abstract Adaptive behavior requires that behaviorally relevant signals gain access to neural circuits guiding action. The thalamus has long been proposed to regulate information flow to cortical and subcortical systems, yet whether it also tracks internally generated goal signals remains unclear. Here, we show that neurons in the paraventricular thalamus (PVT) projecting to the nucleus accumbens (NAc) encode the motivational value of safety during active avoidance.
Local Regulation of Striatal Dopamine Release Shifts from Predominantly Cholinergic in Mice to GABAergic in Macaques
acetylcholine dopamine sensor nicotinic receptors primates voltammetry Significance Statement Dopamine plays a vital role in striatal function, influencing both essential physiological processes and the development of debilitating brain disorders. Most of our current understanding of dopamine release and regulation stems from rodent studies. Investigating the similarities and differences between rodent and primate dopamine systems will improve translatability of findings from rodents to humans.
Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking - Neuropsychopharmacology
Abstract The transition from hedonic alcohol drinking to problematic drinking is a hallmark of alcohol use disorder that occurs only in a subset of drinkers. This transition requires long-lasting changes in the synaptic drive and the activity of striatal neurons expressing dopamine D1 receptor (D1R). The molecular mechanisms that generate vulnerability in some individuals to undergo the transition are less understood.
A role for corticotropin-releasing factor signaling in the lateral habenula and its modulation by early-life stress
Stress hormones, such as CRF (also known as CRH), inhibit the “reward” signals provided by dopamine signaling in the brain after or in anticipation of a given action. Potentially because of this, severe or chronic stress is associated with depression and can impair decision-making, and early-childhood stress is linked to long-term mental health problems and behavioral disorders. Authement et al.
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