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1 Introduction Canine hypoadrenocorticism (HA) is characterized by glucocorticoid (and usually mineralocorticoid) insufficiency (1). Dogs with primary hypoadrenocorticism typically present with vague and variable clinical signs, most commonly including lethargy, gastrointestinal disturbances (vomiting, diarrhea, anorexia, and, less commonly, hematemesis and melena), weight loss, and occasionally collapse.
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