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Articles by Michael Fichter
cDC1 Subtype‐Specific In Vivo Targeting of Liposomes
1 Introduction In the field of nanocarriers (NCs) for drug delivery, a general distinction is made between passive and active targeting. While the result of passive targeting is mostly determined by carrier size, active targeting can employ energy-dependent biological transport processes to overcome physical barriers.
Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups
1 Introduction Over the last decades immunotherapy has gained much attention as promising fourth pillar in oncology.
You Don’t Need Another AI Tool - You Need This One System
Stop asking “What can AI do for me?” — and start asking “How can AI amplify my thinking?” Last Sunday, I ran the Wings for Life World Run — a charity race where everyone starts at the same time, and a car chases you down from behind. I had set an ambitious goal: run at least 30 kilometers. I ended up with 32. But here’s the twist: I trained and planned the entire race with ChatGPT. No human coach. No expensive app. I fed ChatGPT my recent training history and goals.
The 4-Step Decision Framework That Helps High Performers Stop Procrastinating and Start Making Progress
Bonus: Free Template Included to Apply This Framework Today Michael Fichter · Follow 5 min read · -- In 2009, Captain Chesley “Sully” Sullenberger made a life-or-death decision in just 208 seconds. After hitting birds and losing both engines, he quickly chose to land on the Hudson River. That decision saved 155 lives. Sully later shared that while he believed he could do it, he also vividly imagined what he could lose if he was wrong. What made the difference?
How to Stop Drifting Through Your Workday (Like Gus the Penguin)
Member-only story A powerful framework to regain control of your focus and time. Michael Fichter · Follow 6 min read · -- Image Credit: Dall-E Did you hear about Gus, an emperor penguin from Antarctica? He drifted away more than 3400km from his home and appeared on a sandy beach in Western Australia in November 2024. While this might be a rare incident, it’s not too different from what happens to us every day.
3 Productivity Improvements I Made This Year (Inspired by Neapolitan Pizza)
What I learned from a 5-euro pizza about working smarter, not harder. Michael Fichter · Follow 4 min read · -- Photo by Alexandra Gorn on Unsplash I went on a summer trip to Italy with my spouse ten years ago. Starting in Munich, we traveled by train through iconic cities like Verona, Venice, Bologna, Florence, and Rome before arriving at our final destination, Naples. It was a magical journey.
Nanobodies Outperform Antibodies - Rapid Functionalization with Equal In Vivo Targeting Properties
1 Introduction Recently, with the development of therapeutical nanovaccines, the concept of addressing the immune system directly by vaccination has prompted a new high interest in the treatment of tumors via anti-tumor-nanovaccines. These nanovaccines – as immunotherapy in general – provide a means of avoiding the administration of large doses of harmful drugs and limiting the resulting side effects, which occur for example during chemotherapy.
Interfacial Denaturation at the Droplet Simplifies the Formation of Drug‐Loaded Protein Nanocapsules to Enhance Immune Response of Cells
1 Introduction Several challenges can prevent the translation of reported nanocarrier designs to clinical use. These hurdles include the (complex) chemistry required for their synthesis and manufacture, the use of toxic reagents, and the low encapsulation efficiency of therapeutic payloads.[1] Hence, only a small number of nanocarrier designs have been approved by regulatory bodies such as the FDA (Food and Drug Administration) and EMA (European Medical Agency).
Read This If You Fear Losing Your Job To AI
Read This If You Fear Losing Your Job To AI To conquer your fear of AI’s impact on your job, it’s crucial to understand the root causes. We’ll explore the 4 primary reasons for this fear: • Reason #1: You might not want to change. • Reason #2: You might not understand the impact of AI. • Reason #3: You might not understand why humans excel over AI. • Reason #4: You might not have time to learn or not know what to learn. Let’s dive into each one and discover how to address them.
Delivery of Immunostimulatory Cargos in Nanocarriers Enhances Anti-Tumoral Nanovaccine Efficacy
1. Different Factors Establishing the Immunosuppressive Tumor Microenvironment The effective treatment of cancer still holds many challenges due to the heterogeneity of tumors in patients. Moreover, different mechanisms of the immune system are affected by tumor cell alterations.
What Running up a Mountain Every Week Taught Me About Setting Goals
"What Running up a Mountain Every Week Taught Me About Setting Goals" is published by Michael Fichter in ILLUMINATION.
The Role of LFA-1 for the Differentiation and Function of Regulatory T Cells—Lessons Learned from Different Transgenic Mouse Models
Open AccessReview by Tanja Klaus 1, Alicia Wilson 2, Michael Fichter 1,3, Matthias Bros 1, Tobias Bopp 2 and Stephan Grabbe 1,* 1 Department of Dermatology, University Medical Center Mainz, 55131 Mainz, Germany 2 Institute for Immunology, University Medical Center Mainz, 55131 Mainz, Germany 3 Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany * Author to whom correspondence should be addressed. Int. J. Mol. Sci.
Keep These 5 Innovation Factors in Mind to Understand Why ChatGPT Succeeded So Quickly
By Michael Fichter How technological innovations have better chances of getting adopted rapidly. Forrester Research analyst Rowan Curran described ChatGPT as the " iPhone moment for AI ". "iPhone moments" are technological breakthroughs. They completely transform an industry or the way we live our lives.
6 Exercises That Are Worth Your Time and Help To Find Your Dream Job
By Michael Fichter Get to know yourself better before you change paths when you don't know what you want to do. Some people know in life already what they have wanted to do since they were a child. Some of us, however, are more like my 5-year-old daughter. Whenever she is asked what she wants to do when she is a grown-up, it is something...
5 Fool-Proof Ways to Ensure You Will Finish Your Next Online Course
Lessons from finishing 30+ MOOCs. "5 Fool-Proof Ways to Ensure You Will Finish Your Next Online Course" is published by Michael Fichter in ILLUMINATION.
How ChatGPT Saves You Time in Your Everyday Life as a Parent
Let Artificial Intelligence do the job. As a busy parent, you probably don’t have a lot of free time to keep up with the latest technologies. But, what if I told you that there’s a tool out there that could make your life a little bit easier? Meet ChatGPT, a state-of-the-art language generation model developed by OpenAI. In this article, you will learn how ChatGPT can help you with tasks such as chatbots, language translation, and text completion.
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