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Articles by Michael Jelinek
Radiation Therapy in the Management of Head and Neck Mucosal Melanoma
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Off the Top of Our Head
The current standard of care for locally advanced cutaneous squamous cell carcinoma consists of upfront resection followed by adjuvant radiation in the presence of high-risk features. In this case, several factors make surgery less desirable. We do not know whether there is tumor involvement of the sagittal sinus. Invasion of the sagittal sinus would preclude upfront surgery. Additionally, the extent of resection would require a large reconstruction with free tissue transfer.
Implications of the UK Biobank prognostic study for preventive cardiology
In 2013, Hemingway et al. introduced the concept of prognostic research as opposed to aetiological research. The PROGRESS group regard prognostic research as fundamental to clinical and public health research.1–4 Argyridou et al. have applied these concepts in 298,829 subjects from the UK Biobank who were free of cancer and cardiovascular disease at baselines.5 These subjects completed nutritional and physical activity questionnaires at baseline and were followed up for a median of 6.9 years.
Upregulation of vitamin D-binding protein is associated with changes in insulin production in pancreatic beta-cells exposed to p,p′-DDT and p,p′-DDE
Abstract Persistent organochlorine pollutants (POPs) gradually accumulate in the human organism due to their presence in the environment. Some studies have described a correlation between the level of POPs in the human body and the incidence of diabetes, but we know little about the direct effect of POPs on pancreatic beta-cells.
Epidermal Growth Factor Receptor Blockade in Head and Neck Cancer: What Remains?
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that belongs to the ErbB family. Alterations in EGFR have long been considered an oncogenic stimulus in head and neck squamous cell carcinoma (HNSCC). Observed EGFR modifications in HNSCC include overexpression, amplification, and activating mutations.
Threshold body mass index and sex-specific waist circumference for increased risk of heart failure with preserved ejection fraction
1. Vasan, RS, Xanthakis, V, Lyass, A Epidemiology of left ventricular systolic dysfunction and heart failure in the Framingham study: An echocardiographic study over 3 decades. JACC Cardiovasc Imaging 2018; 11: 1–11. Google Scholar | Crossref | Medline 2. Gong, FF, Jelinek, MV, Castro, JM Risk factors for incident heart failure with preserved or reduced ejection fraction, and valvular heart failure, in a community-based cohort. Open Heart 2018; 5: e000782. Google Scholar | Crossref | Medline 3.
What can be learnt from an atypical population?
Hypertension affects one in three of people throughout the world and is the leading cause of preventable deaths world-wide.1 However, a wide variety of genetic and environmental factors may account for the prevalence of hypertension in different regions of the world.2 Intranational surveys of the prevalence of hypertension might be expected to reduce the influence of both disparate genetic and environmental factors in the genesis and outcomes of hypertension locally.
Prediction of incident heart failure by serum amino‐terminal pro‐B‐type natriuretic peptide level in a community‐based cohort
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Research Article Prediction of incident heart failure by serum amino‐terminal pro‐B‐type natriuretic peptide level in a community‐based cohort Duncan J. Campbell Corresponding Author E-mail address: dcampbell@svi.edu.au St. Vincent's Institute of Medical Research, , Fitzroy, Australia University of Melbourne, , Parkville, Australia St. Vincent's Hospital, , Melbourne, Australia Corresponding author.
Implications Of Cardio-respiratory Fitness On The Performance Of Exercise Tests
Publication HistoryPublished online: August 28, 2018Accepted: July 24, 2018; Received in revised form: April 30, 2018; Received: November 16, 2017;
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