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1. Introduction Amyotrophic lateral sclerosis (ALS) is one of the major adult-onset neurodegenerative disorders, with a prevalence in the United States of 5 in 100,000 people (Mehta et al., 2022). The disease is characterized by the degeneration of motor neurons of the motor cortex, brainstem, and spinal cord, resulting in progressive muscle weakness, paralysis and eventual respiratory failure (Masrori and Van Damme, 2020).
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