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Articles by Michael Menzel
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AI & Machine Learning Gemini 3.1 Flash-Lite is now generally available on Gemini Enterprise Agent Platform Gemini 3.1 Flash-Lite is now generally available. Designed for ultra-low latency, high-volume tasks, and unmatched cost-efficiency, Flash-Lite is already transforming how applications are built at scale.
Implementing whole genome and transcriptome sequencing for cancer patients in routine healthcare: a comprehensive guide to costing
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Abstract Molecular characterisation of solid tumours contributes to a precise diagnosis and can uncover a range of drug targets and biomarkers, improving patient management. Whole genome sequencing (WGS) combined with whole transcriptome sequencing (WTS) is the most comprehensive approach in molecular cancer diagnostics and is therefore becoming increasingly integrated in clinical care.
By Christian Altbürger, Michael Menzel, Susanne Beck, Katja Lorenz, Markus Ball, Martina Kirchner, Fabian Schnecko, Andreas Jung, Frederick Klauschen, Tobias Grob, David Horst, Daniela Hirsch, Matthias Evert, Peter Schirmacher, Jan Budczies, Daniel Kazdal, Albrecht Stenzinger, Marie-Luise Brygider, Carolin Ploeger, Andy Kahles
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Nature
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Correction: Diagnostic whole transcriptome sequencing in a series of 1233 FFPE solid tumor samples - British Journal of Cancer
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Correction to: British Journal of Cancer https://doi.org/10.1038/s41416-025-03307-8, published online 14 January 2026 In this article, the author’s name, Olaf Neumann, was incorrectly written as Olaf Neuman. The original article has been corrected.
By Markus Ball, Susanne Beck, Tina Fuchs Verified, Katja Lorenz, Alejandro Robles, Michael Allgäuer, Anna-Lena Volckmar, Iordanis Ourailidis, Regine Brandt, Petros Christopoulos, Michael Thomas, Annette Fink, Olaf Neumann, Michael Menzel, Martina Kirchner, Thoas Fioretos, Peter Schirmacher, Solange Peters, Jan Budczies, Albrecht Stenzinger, Daniel Kazdal, Darius Wlochowitz, Christiane Zgorzelski, Hannah Goldschmid, Huriye Seker-Cin, Fabian Schnecko
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Nature
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Diagnostic whole transcriptome sequencing in a series of 1233 FFPE solid tumor samples - British Journal of Cancer
Abstract Whole Transcriptome Sequencing (WTS) is a comprehensive alternative to targeted panels for detecting gene fusions and splice variants. To integrate WTS into clinical diagnostics, we compared its performance against established fusion assays (Archer FusionPlex and TSO500 RNA). WTS was evaluated in an initial cohort of 64 FFPE tumor samples, and quality control (QC) thresholds were defined based on missed fusions correlating with low tumor cell content (TCC < 40%).
CG>TG mutation frequency as negative predictor of homologous recombination deficiency in ovarian and breast cancer - Communications Biology
Abstract Homologous recombination deficiency (HRD) is a predictive biomarker for PARP inhibition and platinum-based chemotherapy. While copy number alteration-based scores such as HRDsum = LST + TAI + LOH are included in therapy approvals, single base substitutions (SBS) are underinvestigated as predictors of HRD. WES data of the TCGA pan-cancer cohort and an in-house ovarian cancer cohort were annotated by alterations in BRCA1/2 and additional genes causative of HRD.
Tumour mutational burden: clinical utility, challenges and emerging improvements - Nature Reviews Clinical Oncology
Abstract Tumour mutational burden (TMB), defined as the total number of somatic non-synonymous mutations present within the cancer genome, varies across and within cancer types. A first wave of retrospective and prospective research identified TMB as a predictive biomarker of response to immune-checkpoint inhibitors and culminated in the disease-agnostic approval of pembrolizumab for patients with TMB-high tumours based on data from the Keynote-158 trial.
Das Märchen von der neuen Salzburger Naturchefin
Salzburgs Landeshauptmann konnte gar nicht anders, als Marlene Svazek den Umwelt- und Naturschutzteppich auszurollen. Würden Sie einen Fleischhauer zum Tierschutzbeauftragten machen? Nein? Jetzt seien Sie mal nicht so streng. In Salzburg nämlich, da ist etwas ganz Artverwandtes möglich! Dort trug sich im vergangenen Jahr Folgendes zu: Es war einmal ein Landeshauptmann (LH), der ganz deutlich sah, wie sich der heile Himmel über Salzburg verdüsterte.
Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients - npj Precision Oncology
Abstract A growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmentation-based detection of copy number alterations (CNAs), and accurate determination of complex biomarkers including tumor mutational burden (TMB), homologous recombination repair deficiency (HRD), and microsatellite instability (MSI).
Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis - Cell Death Discovery
Abstract TP53 is the most frequently mutated gene in human cancer. While no TP53-targeting drugs have been approved in the USA or Europe so far, preclinical and clinical studies are underway to investigate targeting of specific or all TP53 mutations, for example, by restoration of the functionality of mutated TP53 (TP53mut) or protecting wildtype TP53 (TP53wt) from negative regulation.
100% clean energy will benefit the health and well-being of all Minnesotans
Community Voices features opinion pieces from a wide variety of authors and perspectives. (Submission Guidelines) Michael Menzel As members of the medical and nursing professions, we applaud the introduction of legislation that would update Minnesota’s renewable energy standard to at least 80 percent by 2035 — and would get Minnesota to 100 percent clean energy by 2050. We are also pleased to see Gov.
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