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Articles by Michael Sharp
The hidden balance sheet risk in insurance payments
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Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture
Loading metrics Open Access Peer-reviewed Research Article Citation: Soetomo SA, Sharp MF, Crismani W (2025) Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture. PLoS One 20(9): e0332860. https://doi.org/10.1371/journal.pone.0332860 Editor: Zu Ye, Zhejiang Cancer Hospital, CHINA Received: May 14, 2025; Accepted: September 4, 2025; Published: September 22, 2025 Copyright: © 2025 Soetomo et al.
Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture
Abstract Synthetic lethality describes a genetic relationship where the loss of two genes results in cell death, but the loss of one of those genes does not. Drugs used for precision oncology can exploit synthetic lethal relationships; the best described are PARP inhibitors which preferentially kill BRCA1-deficient tumours preferentially over BRCA1-proficient cells. New synthetic lethal targets are often discovered using genetic screens, such as CRISPR knockout screens.
Clinical and Genetic Spectrum of Fanconi Anaemia in Australia and New Zealand.
The authors have declared no competing interest. W.C. receives a fellowship and funding related to this work from the Australian National Health and Medical Research Council and Victorian Cancer Agency (MCRF21006, GNT1129757, GNT2030115). SVI receives Operational Infrastructure Support from the Victorian State Government. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Biallelic FANCA variants detected in sisters with isolated premature ovarian insufficiency
1 INTRODUCTION Premature ovarian insufficiency is a leading cause of infertility affecting up to 4% of women.1 It is characterised by loss or lack of ovarian activity before the age of 40, manifesting as amenorrhea and elevated follicle stimulating hormone (FSH). Current clinical guidelines2 recommend cytogenetic analysis and investigation of a single causative gene, Fragile X Messenger Ribonucleoprotein 1 (FMR1), which are responsible for ~15% of cases collectively.
Sponsor a Syrian Refugee Family in... by Michael Sharp
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