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Michael Ugrumov

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Articles by Michael Ugrumov

Changes in gene expression of tyrosine hydroxylase, its regulating transcription factors, dopamine receptors in striatal neurons after their dopaminergic denervation

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By Dmitry Troshev, Anna Kolacheva, Michael Ugrumov, Alyona Antonova
| Nature Verified
Abstract Among the priorities in neurology is the development of pathogenetic treatment for Parkinson’s disease (PD). Striatal neurons capable of expressing the tyrosine hydroxylase gene (Th) and containing this enzyme represent a potential target for such therapy. Transgenic mice with the green fluorescent protein gene under the Th promoter were used to model PD via 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine neurotoxin.
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LUHMES Cells: Phenotype Refinement and Development of an MPP+-Based Test System for Screening Antiparkinsonian Drugs

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By Michael Ugrumov, Sergei V. Beliakov, Victor Blokhin, Sergey A. Surkov
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Sergei V. Beliakov †, Victor Blokhin †, Sergey A. Surkov and Michael V. Ugrumov * Laboratory of Neural and Neuroendocrine Regulations, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 119334 Moscow, Russia * Author to whom correspondence should be addressed. † These authors contributed equally to this work. Int. J. Mol. Sci.
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