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Articles by Michael Zollo
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Abstract Covalent inhibitors that do not rely on hijacking enzymatic activity have mainly been limited to those targeting cysteine residues. The development of such cysteine-directed covalent inhibitors has greatly profited from the use of competitive residue-specific proteomics to determine their proteome-wide selectivity. Several probes have been developed to monitor other amino acids using this technology, and many more electrophiles exist to modify proteins.
Lubricity, wear prevention, and anti-biofouling properties of macromolecular coatings for endotracheal tubes
Lubricity, wear prevention, and anti-biofouling properties of macromolecular coatings for endotracheal tubes† Macromolecular coatings can improve the surface properties of many medical devices by enhancing their wetting behavior, tribological performance, and anti-biofouling properties – and covalent coatings produced from mucin glycoproteins have been shown to be very powerful in all those aspects.
Lubricity, Wear Prevention, and Anti-Biofouling Properties of Macromolecular Coatings for Endotracheal Tubes
Lubricity, Wear Prevention, and Anti-Biofouling Properties of Macromolecular Coatings for Endotracheal Tubes Macromolecular coatings can improve the surface properties of many medical devices by enhancing their wetting behavior, tribological performance, and anti-biofouling properties – and covalent coatings produced from mucin glycoproteins have been shown to be very powerful in all those aspects.
Competitive profiling of ligandable cysteines in Staphylococcus aureus with an organogold compound
Competitive profiling of ligandable cysteines in Staphylococcus aureus with an organogold compound† Claudia Schmidt, ‡a Michael Zollo, ‡b Riccardo Bonsignore,ac Angela Casini *a and Stephan M. Hacker *bd Abstract With the idea of exploiting metal templated C–S bond forming reactions to achieve modification of cysteines in bacterial proteins, a cyclometalated Au(III) compound was explored in a competitive chemoproteomic approach in S. aureus cell extracts.
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