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Introduction Liver transplantation (LTx) is the only treatment for end-stage liver disease. To prevent allograft rejection after transplantation, the use of immunosuppressive drugs (IS) is indispensable. However, in a significant proportion of LTx recipients, long-term use of IS leads to severe side effects such as (persistent) infections, metabolic disorders (e.g. diabetes, dyslipidemia), renal dysfunction, cardiovascular disease, and malignancies [1–6].
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