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1 INTRODUCTION Fibroblasts play various roles in maintaining tissue homeostasis and are crucial in shaping the tumor microenvironment (TME) (Sahai et al., 2020). It is well known that fibroblasts, alongside their self-produced interstitial extracellular matrix (ECM), form functional units both in vivo and in vitro (Cukierman et al., 2001).
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