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Mihir K Rao

As seen in: Wiley Online Library, BioRxiv
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Articles by Mihir K Rao

Nucleoporin93 limits Yap activity to prevent endothelial cell senescence

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By Tung Nguyen, Mihir K Rao, Shaiva P Dhyani, Biophysics The
| Wiley Online Library Verified
BCA brachiocephalic artery CVD cardiovascular disease DEG differentially expressed gene DEX dexamethasone EC endothelial cell HREC human retinal endothelial cell LDH lactate dehydrogenase MLEC mouse lung endothelial cell NPC nuclear pore complex RGG rev-glucocorticoid receptor-GFP SA-βGal senescence-associated β-Galactosidase TF transcription factor VP Verteporfin 1 INTRODUCTION Human aging is defined as a chronic state of low-grade inflammation, wherein pro-inflammatory factors gradually...
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Nucleoporin93 (Nup93) Limits Yap Activity to Prevent Endothelial Cell Senescence

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By Tung Nguyen, Justin Banks, Mihir K Rao, Shaiva P Dhyani
| BioRxiv
Abstract Endothelial cells (ECs) form the innermost lining of the vasculature and serve a pivotal role in preventing age-related vascular disease. Endothelial health relies on the proper nucleocytoplasmic shuttling of transcription factors via nuclear pore complexes (NPCs). Emerging studies report NPC degradation with natural aging, suggesting impaired nucleocytoplasmic transport in age-related EC dysfunction.
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