1 INTRODUCTION Ischemic stroke is the main cause of disability in the United States and a significant cause of death globally.1 Every year, there are about 800,000 ischemic strokes in the United States, 600,000 of which are recurrent events.2 Globally, one of six people has had an ischemic stroke in their lifetime, and 14 million people experience a stroke each year.3 However, aside from reperfusion therapy, very few approaches are available clinically to protect the brain against ischemic...
