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Abstract B7-H4 is a promising antibody-drug conjugate (ADC) target with high expression in several solid tumors and limited expression in normal tissue. B7-H4 negatively regulates T-cell function, and high expression of B7-H4 is associated with disease progression. AZD8205 (puxitatug samrotecan [Puxi-Sam]) is a novel B7-H4–directed ADC with a stable cleavable linker and a bystander-capable topoisomerase-1 (TOP1) inhibitor payload.
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