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1 Introduction Hypertrophic scar is one of the most common cutaneous complications following burn injury, with a prevalence exceeding 70% in Asian populations [1]. Facial burns account for 47.7% of all forms of burns, second only to burns on the upper extremity areas [2].
To in vitro simulate the process of drug delivery, artificial cell-free 3D matrix based on rat tail collagen type I was used to model the biochemical components and mechanical properties of scar ECM. The Nile-red-loaded MPs were sprinkled on the top surface of the collagen hydrogel, penetrating downward under gravity. Confocal microscopy revealed that after 24 h, COLA1-decorated PLGA MPs displayed a more spatial distribution than enzyme-free PLGA MPs (Figure 5A).
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