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Articles by Ming You
In situ vaccination for the treatment of localized cancer and the prevention of metastatic disease
Abstract In situ vaccination (ISV) is a local tumor-directed immunotherapy strategy that uses a treated tumor as an endogenous, patient-specific source of tumor antigens and a site of immune activation, with the goal of converting local treatment into systemic and durable antitumor immunity.
A hazard assessment framework for landslide-induced impulse waves in high-dam reservoir
Abstract Hazard assessment of landslide-induced impulse wave in high-dam reservoirs requires explicit quantification of the cascading processes from slope instability to wave impact. Previous methods often decouple the failure probabilities of slopes from hydrodynamic consequences, hardly considering the nonlinear amplification of cascading hazards.
Targeting mitochondria for the treatment of neurodegenerative diseases
Abstract Mitochondria are central regulators of cellular metabolism, redox balance, calcium signaling, and cell survival, making them essential for neuronal function. Because neurons rely heavily on mitochondrial oxidative phosphorylation to meet their high energetic demands, mitochondrial dysfunction has emerged as a key pathogenic driver in major neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.
Mitochondria-targeted strategies in tumor immunity
1 Introduction Mitochondria are essential intracellular organelles that primarily facilitate energy production and metabolic regulation (1). They generate adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS), thereby providing cells with the energy required for various functions (2).
Insights Into How Glyphosate Constrains Conidial Germination but Stimulates Morphological Transformation of the White Leaf Spot Pathogen Neopseudocercosporella capsellae in Glyphosate‐Tolerant Rapeseed (Brassica napus)
1 Introduction Rapeseed (canola, Brassica napus) is the second-largest oilseed crop worldwide after soybeans (STATISTA 2025). Australia alone produced 6.8 million tonnes in 2022, including 3 million tonnes from Western Australia (Australian Bureau of Statistics 2023). Weeds are a significant global threat to crop yields and quality; for example, in Australia and the United States of America, annual expenditure on weed management surpasses $US30 billion (Abouziena and Haggag 2016).
First Report of Genomic Regions Associated With White Leaf Spot Resistance in Brassica napus
1 Introduction Climate change is altering the agroclimatic conditions that influence plant pathogen emergence and distribution, contributing to disease outbreaks (Ristaino et al. 2021; Yuan et al. 2023). Distribution modelling of crop pests and pathogens has revealed an overall latitudinal shift because of increased crop availability and favourable changes in temperature and rainfall (Bebber et al. 2013; Bebber 2015).
Long Lasting Fragrance Coaxial Essential Oil Nanofiber Membrane: Fabrication, Characterization and Antibacterial Properties
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description app57234-sup-0001-FigureS1.docxWord 2007 document , 71.3 KB Figure S1.GC–MS spectra of CEo. References 1, , , , and , “Preparation and Characterization of Polysulfone Microcapsules for Perfume Release,” Chemical Engineering Journal 179, no. 1 (2011): 394–403.
Magnetic-chemotactic hybrid microrobots with precise remote targeting capability
Magnetic-chemotactic hybrid microrobots with precise remote targeting capability Micro/nanorobots (MNRs) hold great promise for various applications due to their capability to execute complex tasks in hard-to-reach narrow cavities. However, the developed magnetic MNRs, as marionettes of external magnetic fields, lack building-in intelligence for self-targeting, while chemotactic MNRs suffer from limited self-targeting range.
Globally Guided Deep V-Network-Based Motion Planning Algorithm for Fixed-Wing Unmanned Aerial Vehicles
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention - npj Precision Oncology
Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a therapeutic target for breast and other cancers. TOP2A-specific Th1-promoting epitopes with optimal binding affinity to MHC II were identified using a combined scoring system.
Plant growth stage and Phoma medicaginis inoculum concentration together determine severity of Phoma black stem and leaf spot and consequent phytoestrogen production in annual Medicago spp
ORIGINAL ARTICLE This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/ppa.13770. Abstract Phoma black stem and leaf spot disease (Phoma medicaginis) not only destroys annual Medicago spp.
Reply to: “Inconsistent prediction capability of ImmuneCells.Sig across different RNA-seq datasets”
Replying to X. Xiao et al. Nature Communication https://doi.org/10.1038/s41467-021-24303-5 (2021). In their commentary on our paper1, Xiao et al.2 make a point that the predictive performance of ImmuneCells.Sig is inconsistent. This is mainly due to the batch effect across different RNA-seq data sets (Fig. 1a). The relatively poor generalization of gene expression profiling (GEP) is common in predicting immunotherapy response.
Reversal of the Apoptotic Resistance of Non-Small-Cell Lung Carcinoma towards TRAIL by Natural Product Toosendanin
Previous studies and clinical trials showed that some NSCLC cells are relatively resistant to TRAIL therapy8. In this study, we first investigated the apoptotic effects of TRAIL and TSN on A549 cells because this cell line is relatively TRAIL-resistant. The chemical structure of TSN is shown in Fig. 1A.
Pathogen Biocontrol Using Plant Growth-Promoting Bacteria (PGPR): Role of Bacterial Diversity
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
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