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Results Evidence Base Searches identified 11,123 potential citations. After title and abstract screening, 41 studies met inclusion criteria, including 15 addressing pharmacologic treatments and 8 addressing dietary treatments. Common reasons for full-text exclusions were as follows: (1) <80% in age group of interest, (2) <30 patients in nonrandomized studies, and (3) focus on neonates. Study details and treatment/patient characteristics are summarized in eTables 1–4, links.lww.com/WNL/C434.
Seizure Freedom Eight retrospective prestudies/poststudies (in 9 articles) included 188 infants18,20,23,26,28-30,32,33 and reported on seizure freedom from 6 months to mean 4.3 years after surgery (Table 1). One study23 did not report the follow-up interval for the subgroup of included patients. All studies were assessed as a high risk of bias for many reasons including lack of a control group. Seizure freedom rates at 1 year ranged from 7% to 76% (Figure 2).
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