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Basement membrane-related genes (BMRGs) were screened and identified from the UniProt database (accessed on 12 June 2023). RNA-Seq expression data and clinical details for BLCA patients were obtained from two sources: the TCGA-BLCA cohort within The Cancer Genome Atlas database (accessed on 15 June 2023) and the GEO BLCA cohort (GSE13507). The clinical data encompassed age, gender, stage, TNM stage, survival status, and overall survival (OS).
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Receptor signaling relays on intracellular events amplified by secondary and tertiary messenger molecules. In cardiomyocytes and smooth muscle cells, cyclic AMP (cAMP) and subsequent calcium (Ca2+) fluxes are the best characterized receptor-regulated signaling events. However, most of receptors able to modify contractility and other intracellular responses signal through a variety of other messengers, and whether these signaling events are interconnected has long remained unclear.
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