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Articles by Minggui Wang
Methicillin-resistant Staphylococcus aureus - Nature Reviews Disease Primers
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of antimicrobial-resistant infection worldwide. The spectrum of diseases caused by MRSA range from uncomplicated skin and soft-tissue infections to life-threatening invasive infections such as bacteraemia, pneumonia, osteomyelitis and endocarditis.
Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions.
Faculty, Staff and Student Publications Publication Date 2-17-2024 Journal The Journal of Infectious Diseases PubMedCentral® Posted Date 9-20-2023 PubMedCentral® Full Text Version Post-print Abstract Background: Carbapenem-resistant Acinetobacter baumannii (CRAb) is 1 of the most problematic antimicrobial-resistant bacteria.
Dynamic balance of CRISPR-Cas immunity and resistance plasmid anti-immunity mediated by a bifunctional protein AcrIE10
Abstract Despite targeting by CRISPR-Cas system, antimicrobial resistance plasmids are prevalent in clinical isolates of carbapenem-resistant Klebsiella pneumoniae which represent a major public health threat. A stable co-existence of plasmids and CRISPR-Cas systems is mediated by anti-CRISPR (Acr) proteins.
Can we escape from top-priority ESKAPE pathogens?
Abstract The ESKAPE pathogens—Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.—are designated by the World Health Organization as critical-priority multidrug-resistant organisms. These bacteria are leading contributors to the global antimicrobial resistance crisis, significantly increasing morbidity, mortality, and healthcare costs worldwide.
Fasting-induced ketogenesis sensitizes bacteria to antibiotic treatment
Keywords antibiotics antibiotic treatment drug susceptibility fasting metabolism anorexia ketogenesis ketone body acetoacetate sepsis Introduction The spread of drug-resistant bacteria and the diminishing of the antibiotic pipeline threaten the return of the preantibiotic era. Ensuring effective antimicrobial therapy has become an overarching goal to combat this threat,1 which requires a comprehensive understanding of the mechanisms that determine antibiotic efficacy.
Biphasic bactericidal activity of nitroxoline against Acinetobacter baumannii isolates from urinary tract infections
Abstract Acinetobacter baumannii is a critical pathogen which can cause hospital-acquired infections, particularly urinary tract infections (UTIs). The antimicrobial resistance (AMR) of A. baumannii is rising which poses a significant challenge to clinical management. Nitroxoline, an old antibiotic for treating uncomplicated UTIs, has gained renewed interest as a potential therapeutic option. Here, we investigates the bactericidal activity of nitroxoline against 34 A.
Effects of Biochar Application on Tomato Yield and Fruit Quality: A Meta-Analysis
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Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study
Summary Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global threat. We therefore analysed the bacterial characteristics of CRKP infections and the clinical outcomes of patients with CRKP infections across different countries. Methods In this prospective, multicentre, cohort study (CRACKLE-2), hospitalised patients with cultures positive for CRKP were recruited from 71 hospitals in Argentina, Australia, Chile, China, Colombia, Lebanon, Singapore, and the USA.
Fe3O4/PANI/MnO2 Core-Shell Hybrids as Advanced Adsorbents for Heavy Metal Ions
Multifunctional magnetic adsorbents containing MnO2 and polyaniline (PANI) with optimized adsorption properties toward heavy metal ions have been developed. Specifically, Fe3O4 spheres were chosen as the magnetic core, followed by PANI and MnO2 coating, realizing the formation of Fe3O4/PANI/MnO2 core-shell hybrids. The as-synthesized Fe3O4/PANI/MnO2 core-shell hybrids showed hierarchical structure with large surface area and high magnetic saturation value.
Achieving global targets for antimicrobial resistance
After decades of neglect, antimicrobial resistance (AMR) has captured the attention and concern of the public health community and global leaders. In September 2016, a high-level meeting of the United Nations General Assembly (UNGA) will discuss how countries can cooperate to preserve global access to effective antimicrobials.
Achieving global targets for antimicrobial resistance
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