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1 Introduction Tumor vaccines using defined antigens have long been employed to treat cancers by mobilizing host immunity.[1] However, the heterogeneity and complexity of antigens across patients as well as the high expense of identifying patient-specific antigen mutations impede their widespread clinical use.[2] To overcome these limitations, autologous tumors have been used to produce whole tumor cell vaccines (namely personalized cancer vaccines).[3] These encompass the full repertoire of...
Combination of Mitochondrial Targeting Doxorubicin with Bcl-2 Function Converting Peptide NuBCP-9 for Synergistic Breast Cancer Metastasis Inhibition Jiatao Yang, Qiuyi Li, Rui Zhou, Minglu Zhou, Xi Lin, Yucheng Xiang, Dandan Xie, Yuan Huang and Zhou Zhou Abstract Distant organ metastasis is the main cause of death in breast cancer patients. Evidences have shown that mitochondria also play a crucial role in tumor metastasis, except for as apoptosis center.
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