Abstract Objective: To evaluate the association between cognitive reserve (CR) and glymphatic function in mild cognitive impairment (MCI), and to examine whether the relationship between CR and cognition is mediated by glymphatic function. Methods: 113 MCI individuals and 91 healthy controls (HC) were enrolled to assess the glymphatic function by using diffusion tensor imaging along the perivascular space (DTI-ALPS), perivascular space (PVS) ratings, and choroid plexus volume (CPV).
