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Articles by Minjun Yang
Dihydromyricetin confers protection against myocardial ischemia-reperfusion injury by inhibiting ferroptosis through direct targeting of PPARα
Abstract Background: Myocardial ischemia-reperfusion injury (MIRI) remains a therapeutic challenge with limited treatment options. Ferroptosis, characterized by lipid peroxidation, contributes significantly to MIRI pathogenesis. This study investigates whether dihydromyricetin (DHM), a bioactive flavonoid from Ampelopsis grossedentata, alleviates MIRI by inhibiting ferroptosis, and explores its cardioprotective mechanisms.
Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma - Nature Communications
Abstract Neuroblastoma (NB) is one of the most lethal childhood cancers due to its propensity to become treatment resistant.
Constitutional and acquired genetic variants in ARID5B in pediatric B‐cell precursor acute lymphoblastic leukemia
1 INTRODUCTION Constitutional single nucleotide polymorphisms (SNPs) in the ARID5B gene at 10q21.2, which codes for a member of the AT-rich interactive domain (ARID) protein family involved in chromatin-remodeling,1, 2 are associated with an increased risk of developing childhood B cell precursor acute lymphoblastic leukemia (BCP ALL), particularly of the high hyperdiploid (HeH; 51–67 chromosomes) subtype3-11 as well as with an increased risk of relapse of pediatric ALL.6, 7, 9 Two recent...
Vaterite Dissolution: Mechanism and Kinetics
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Phys. Chem. C 2024, XXXX, XXX RETURN TO ARTICLES ASAPPREVC: Chemical and Cata...C: Chemical and Catalytic Reactivity at InterfacesNEXT Morgan P. Milner Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QZ, U.K. , Minjun Yang Centre for Sustainable Materials Processing, School of Chemistry, University of Leicester, Leicester LE1 7RH, U.K. , and * Cite this: J. Phys. Chem.
Overcoming passivation through improved mass transport in dense ionic fluids
Overcoming passivation through improved mass transport in dense ionic fluids Deep Eutectic Solvents (DESs) have recently been shown to be part of a dense ionic fluid continuum between ionic liquids and concentrated aqueous brines. Charge transport was shown to be governed by fluidity, with no discontinuity between molar conductivity and fluidity irrespective of cation, charge density or ionic radius.
Inside Cover: Discovering Electrochemistry with an Electrochemistry‐Informed Neural Network (ECINN) (Angew. Chem. Int. Ed. 13/2024)
Dr. Minjun Yang Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, OX1 3QZ Oxford, UK These authors contributed equally to this work. Search for more papers by this author
The solubility product controls the rate of calcite dissolution in pure water and seawater
The solubility product controls the rate of calcite dissolution in pure water and seawater Quantification of calcite dissolution underpins climate and oceanographic modelling. We report the factors controlling the rate at which individual crystals of calcite dissolved. Clear, generic criteria based on the change of calcite particle dimensions measured microscopically with time are established to indicate if dissolution occurs under kinetic or thermodynamic control.
Discovering Electrochemistry with an Electrochemistry‐Informed Neural Network (ECINN)
The rise of deep learning since the early 2010s has penetrated almost every aspect of the scientific method, from detecting anomalies in observations, using autoencoders1 for the discovery of new physics,2 generating hypotheses using Large Language Models (LLMs),3 exploring experimental space with Bayesian optimization4 and robotic chemistry,5 analyzing experimental data using neural networks and ensemble methods,6 to drawing conclusions with casual inference.7 Of the steps mentioned above,...
Calcifying Coccolithophore: An Evolutionary Advantage Against Extracellular Oxidative Damage
Abstract The evolutionary advantages afforded by phytoplankton calcification remain enigmatic.
AI facilitated fluoro-electrochemical phytoplankton classification
AI facilitated fluoro-electrochemical phytoplankton classification† Haotian Chen, ‡a Samuel Barton,‡b Minjun Yang, a Rosalind E. M. Rickaby,b Heather A. Boumanb and Richard G. Compton *a Abstract Marine phytoplankton is extremely diverse. Counting and characterising phytoplankton is essential for understanding climate change and ocean health not least since phytoplankton extensively biomineralize carbon dioxide whilst generating 50% of the planet's oxygen.
Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia - Nature Communications
Single cell WGS All investigations complied with relevant ethical regulations. Written informed consent was obtained from the patients and/or their guardians according to the Declaration of Helsinki and the study was approved by the Ethics Committee of Lund University, Sweden. No monetary compensation was offered for patient participation.
Does the life cycle stage matter for distinguishing phytoplankton via fluoro-electrochemical microscopy?
15 Bard A.J. Faulkner L.R. Electrochemical Methods: Fundamentals and Applications. 2nd Edition. John Wiley & Sons, To investigate the factors resulting in the different behaviors toward oxidative damage, the total numbers of moles of oxidant generated that could have reacted with the individual cells under mass transport control from the electrode to the cell was calculated using the following expression derived from the Sand equation, 16 Sand H.J. III.
Calcium Carbonate Dissolution from the Laboratory to the Ocean: Kinetics and Mechanism
Abstract Carbonate chemistry: Although calcite dissolution has been extensively studied there appears to be a problem; apparent contradictions, discrepancies between laboratories and inconsistencies with field measurements seemingly pervade the literature. This review highlights how – in some circumstances – a lack of appreciation of the role of mass-transport may have hindered development.
Opto‐Electrochemical Dissolution Reveals Coccolith Calcium Carbonate Content
Abstract Coccoliths are plates of biogenic calcium carbonate secreted by calcifying marine phytoplankton; annually these phytoplankton are responsible for exporting >1 billion tonnes (1015 g) of calcite to the deep ocean. Rapid and reliable methods for assessing the degree of calcification are technically challenging because the coccoliths are micron sized and contain picograms (pg) of calcite.
Single base substitution mutational signatures in pediatric acute myeloid leukemia based on whole genome sequencing
To the Editor: Whole genome sequencing (WGS) of neoplasms not only offers a comprehensive genome-wide detection of gene fusions/other structural variants (SVs), gene mutations, and copy number abnormalities (CNAs) but also provides information on acquired mutational profiles, including localized hypermutations (kataegis) and single base substitution (SBS) mutational signatures.
The oxygen reduction reaction at silver electrodes in high chloride media and the implications for silver nanoparticle toxicity
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Acoustic cavitation generates molecular mercury(II) hydroxide, Hg(OH)2, from biphasic water/mercury mixtures
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Acoustic Cavitation Generates Molecular Mercury (II) Hydroxide, Hg(OH)2, from Biphasic Water/Mercury Mixtures
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Correction: A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated extracellular vesicle enrichment by acoustic trapping to microRNA sequencing
The following information is missing from the Funding statement: This study was also supported by the Swedish Foundation for Strategic Research (SSF) Grant Number SBE13-0049 and the Swedish Research Council (Grants: 2014–03413, 2018–03672). Citation: Ku A, Ravi N, Yang M, Evander M, Laurell T, Lilja H, et al. (2019) Correction: A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated extracellular vesicle enrichment by acoustic trapping to microRNA sequencing.
In‐situ electrochemical X‐ray diffraction: A rigorous method to navigate within phase diagrams reveals β‐Fe1+xSe as superconductor for all x - Rasche - - Angewandte Chemie International Edition - Wiley Online Library
Communication In‐situ electrochemical X‐ray diffraction: A rigorous method to navigate within phase diagrams reveals β‐Fe1+xSe as superconductor for all x Richard G.
Fluoro-electrochemical Microscopy reveals Group Specific Differential Susceptibility of Phytoplankton towards Oxidative Damage
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A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated extracellular vesicle enrichment by acoustic trapping to microRNA sequencing
Loading metrics Open Access Peer-reviewed Research Article Anson Ku , Naveen Ravi, Minjun Yang, Mikael Evander, Thomas Laurell, Hans Lilja, Yvonne Ceder Anson Ku, Naveen Ravi, Minjun Yang, Mikael Evander, Thomas Laurell, Hans Lilja, Yvonne Ceder Published: May 29, 2019 https://doi.org/10.1371/journal.pone.0217507 Figures Abstract Development of a robust automated platform for enrichment of extracellular vesicles from low sample volume that matches the needs for next-generation sequencing...
Fine mapping MHC associations in Graves’ disease and its clinical subtypes in Han Chinese
Recent studies on HLA associations in GD and other diseases suggest that amino acid variants were the major driver conferring risk for diseases rather than the classical alleles. 11 13 In this study, we conducted a fine-mapping study assessing the GD associations with SNP, HLA amino acid variants, two-digit HLA alleles and four-digit HLA alleles simultaneously in Han Chinese populations by the imputation approach in our previous GWAS data.
Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a <i>CEBPE</i> promoter polymorphism
Samples and clinicopathological information were collected with ethical board approval. ALL blast RNA sequencing and genotyping sample collection was approved by the Lund University, nos 2011/289 and 2017/796. Informed consent was granted from all participants. UK GWAS and German GWAS have been previously reported [6, 7]. Briefly, the UK GWAS comprised 824 cases, genotyped using Illumina Human 317 K arrays; WTCC2 controls were of 2699 of 1958 British Birth Cohort and 2501 from the UK Blood Service.
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