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Miriam M. Beichler

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Articles by Miriam M. Beichler

LUBAC PUB domain interactions restrict Met1-linked ubiquitination to prevent murine embryonic lethality and immune pathology

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By John Rizk, Wenxin Lyu, Malin Jessen, Kit Lee, Majken Kjær, Giulia Franciosa, Jesper V. Olsen, Berthe K. Fiil, Dominik Priesmann, Mads Gyrd-Hansen, Frederik Timmermann, Miriam M. Beichler, Max B. Sauerland
| Nature Verified
Abstract Met1-linked ubiquitin assembled by LUBAC coordinates immune receptor signalling and inflammation. The PUB domain of the LUBAC subunit HOIP interacts with PUB-interacting motif-containing proteins, including the deubiquitinases OTULIN and SPATA2-CYLD. Yet, how these interactions regulate LUBAC remains unclear. Here, we investigate the consequences of ablating PUB-interacting motif interactions by generating mice carrying an N101D mutation in the HOIP PUB domain.
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