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Articles by Mirte Scheper
WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse
Filename Description epi70382-sup-0001-TableS1-S4.docxWord 2007 document , 105.4 KB TABLE S1. Electroencephalography-based biomarkers under investigation in epilepsy. TABLE S2. (A) Circulating protein biomarkers investigated in epilepsy. (B) Circulating miRNA biomarkers investigated in epilepsy. TABLE S3. Biomarkers of comorbidities in epilepsy. TABLE S4. Emerging treatment strategies beyond the synapse in epilepsy.
Single-cell profiling of cortical tubers in tuberous sclerosis complex shows molecular structure preservation and massive reorganization of metabolism
Abstract Tuberous sclerosis complex (TSC) is a multisystemic genetic disorder associated with loss-of-function mutations in the TSC1 or TSC2 gene, which lead mTOR pathway hyperactivation and epileptogenesis. Cortical tubers are the hallmark of TSC and represent disorganized cortical structure underlying the generation of focal seizures. Here, we report single-nucleus RNA sequencing in resected cortical tubers vs matched pediatric controls.
Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study
Circulating miRNA and isomiR profiles were screened as biomarkers for epileptogenesis in four different rat models of epileptogenesis. Two days after an epileptogenic insult, alterations of several miRNAs and isomiRs predicted epileptogenesis in a model-specific manner. miR-3085 showed good sensitivity (but low specificity) as a prognostic biomarker for epileptogenesis in all four models.
Levamisole suppresses activation and proliferation of human T cells by the induction of a p53‐dependent DNA damage response
Levamisole (LMS) is a small molecule used in the treatment of idiopathic nephrotic syndrome (INS). The pathogenesis of INS remains unknown, but evidence points towards an immunological basis of the disease. Recently, LMS has been shown to increase the relapse-free survival in INS patients. While LMS has been hypothesized to exert an immunomodulatory effect, its mechanism of action remains unknown. Here, we show that LMS decreased activation and proliferation of human T cells.
Levamisole suppresses activation and proliferation of human T cells by the induction of a p53‐dependent DNA damage response
Levamisole (LMS) is a small molecule used in the treatment of idiopathic nephrotic syndrome (INS). The pathogenesis of INS remains unknown, but evidence points towards an immunological basis of the disease. Recently, LMS has been shown to increase the relapse-free survival in INS patients. While LMS has been hypothesized to exert an immunomodulatory effect, its mechanism of action remains unknown. Here, we show that LMS decreased activation and proliferation of human T cells.
Levamisole suppresses activation and proliferation of human T cells by the induction of a p53-dependent DNA damage response
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Dysregulation of miR‐543 in Parkinson’s disease: impact on the neuroprotective gene SIRT1
Abstract Aims Parkinson’s disease (PD) is a progressive and age-dependent neurodegenerative disease characterized clinically by a variety of motor symptoms and cognitive impairment. PD was initially considered to be a grey matter disease, however, recently, evidence has emerged that white matter changes in PD precede the neuronal loss seen in the grey matter. The cause of these initial white matter changes is yet to be elucidated.
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