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Liver biopsy is not routinely performed in treated chronic hepatitis B. Liver stiffness measurement has been validated for non-invasive liver fibrosis assessment in pre-treatment chronic hepatitis B but has not been assessed for fibrosis monitoring during antiviral therapy. Liver stiffness was systemically monitored by Fibroscan® every 6 months in a cohort of patients with hepatitis B receiving antiviral therapy and compared with liver biopsies at baseline and week 104.
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