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Articles by Modern Management
TIPred: a novel stacked ensemble approach for the accelerated discovery of tyrosinase inhibitory peptides - BMC Bioinformatics
References Casanola-Martin GM, et al. Tyrosinase enzyme: 1. An overview on a pharmacological target. Curr Top Med Chem. 2014;14(12):1494–501. CAS PubMed Google Scholar Kahn V. Effect of kojic acid on the oxidation of DL-DOPA, norepinephrine, and dopamine by mushroom tyrosinase. Pigment Cell Res. 1995;8(5):234–40. CAS PubMed Google Scholar Panzella L, Napolitano A. Natural and bioinspired phenolic compounds as tyrosinase inhibitors for the treatment of skin hyperpigmentation: recent advances. Cosmetics.
Quickly validate and enable manual application uninstall via Intune Company Portal using Graph API
I am back and the titles are getting longer! If you are an Intune admin, you will probably be happy to know that one of the most required features has landed: . One thing you need to be aware of, is that this feature is off by default, which means you will have to manually enable it for every app (lots of clicks)! Or, we can automate with PowerShell and Graph API… What’s the problem?
LDL cholesterol reduction in addition to statins
To prevent atherosclerosis and the associated risks, consistent treatment of cardiovascular risk factors is recommended – this includes in particular the reduction of elevated LDL cholesterol levels. In addition to lifestyle modification and statins, a wide range of newer lipid-lowering drugs are available, including ezetimibe, PCSK9 inhibitors, and bempedoic acid. These can be considered as combination therapies under individual risk-benefit assessment.
Improved prediction and characterization of blood-brain barrier penetrating peptides using estimated propensity scores of dipeptides - Journal of Computer-Aided Molecular Design
Abstract The blood-brain barrier (BBB) is the primary barrier with a highly selective semipermeable border between blood vascular endothelial cells and the central nervous system. Since BBB can prevent drugs circulating in the blood from crossing into the interstitial fluid of the brain where neurons reside, many researchers are working hard on developing drug delivery systems to penetrate the BBB which currently poses a challenge.
StackHCV: a web-based integrative machine-learning framework for large-scale identification of hepatitis C virus NS5B inhibitors - Journal of Computer-Aided Molecular Design
1. Thrift AP, El-Serag HB, Kanwal F (2017) Global epidemiology and burden of HCV infection and HCV-related disease. Nat Rev Gastroenterol Hepatol 14(2):122–132 PubMed Article PubMed Central Google Scholar 2. Khalid H et al (2020) Discovery of novel Hepatitis C virus inhibitor targeting multiple allosteric sites of NS5B polymerase. Infect Genet Evol 84:104371 PubMed Article CAS PubMed Central Google Scholar 3.
Microsoft Teams: How to overcome challenges with Windows Information Protection & Conditional Access
Recently Microsoft announced Microsoft Teams, a new chat-based platform in Office 365. For all mobile platforms (Android, iOS and Windows 10 Mobile) Microsoft released an native app, including a desktop app for Windows 10 and Mac OS X. The Microsoft Teams apps can be downloaded here. After I installed the Microsoft Teams desktop app on Windows 10 I bumped into the following funny message ‘Yikes! Looks like someone pulled the plug on the internet’.
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