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Full Paper Jeffrey W. Bode Corresponding Author E-mail address: bode@org.chem.ethz.ch ETH Zurich, Chemistry and Applied Bioscience, Laboratorium für Organische Chemie, Vladimir Prelog Weg 3, 8093 Zurich, SWITZERLAND Search for more papers by this author PDF ShareShare Abstract A method for the synthesis of rigid nitroxide biradicals with various spatial orientations between the radical centers is reported.
We report the facile formation of trifluoroborate-iminiums (TIMs) from potassium acyltrifluoroborates (KATs) and the transformation of TIMs to α-aminotrifluoroborates by reduction or Grignard addition. Conditions for the hydrolysis of α-aminotrifluoroborates to α-aminoboronic acids, which are important pharmacophores, were established. This new methodology allows access to sterically demanding α-aminoboronic acids that are not easily prepared with currently available methods.
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