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Mujdat Zeybel

As seen in: Gut Journal
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Articles by Mujdat Zeybel

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

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By Timothy Hardy, Mujdat Zeybel, Koç, Christopher Day
| Gut Journal Verified
The main aim of the present study was to ask if differential DNA methylation at the PPARγ promoter can be detected within the pool of cell-free DNA of human plasma and if so then do levels of methylation at this loci correlate with fibrosis stage in NASH. While there is unquestionably a role for gene polymorphisms in the progression of NASH to fibrosis there is also strong evidence for the involvement of lifestyle factors (age, diet, exercise, other comorbidities and so on).
Open in Who Shared Issue with article?

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

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By Timothy Hardy, Mujdat Zeybel, Koç, Christopher Day
| Gut Journal Verified
The main aim of the present study was to ask if differential DNA methylation at the PPAR? promoter can be detected within the pool of cell-free DNA of human plasma and if so then do levels of methylation at this loci correlate with fibrosis stage in NASH. While there is unquestionably a role for gene polymorphisms in the progression of NASH to fibrosis there is also strong evidence for the involvement of lifestyle factors (age, diet, exercise, other comorbidities and so on).
Open in Who Shared Issue with article?

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

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By Koç, Timothy Hardy, Mujdat Zeybel
| Gut Journal Verified
Objective Liver biopsy is currently the most reliable way of evaluating liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Its inherent risks limit its widespread use. Differential liver DNA methylation of peroxisome proliferator-activated receptor gamma (PPAR?) gene promoter has recently been shown to stratify patients in terms of fibrosis severity but requires access to liver tissue.
Open in Who Shared Issue with article?
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