1 Introduction Longevity, once a futuristic ideal, has become a clinical reality at the intersection of regenerative medicine and cosmetic dermatology [1-3]. Aging is now increasingly regarded as a modifiable process, shaped by genetic predisposition, lifestyle factors, and molecular pathways. Over the past 15 years, advancements in stem cell therapy, mitochondrial research, epigenetic reprogramming, and artificial intelligence (AI) have redefined the dermatologic approach to skin aging [4, 5].
