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4.1. Drug Preparation and Synthesis Compounds 1–16 were synthesised using the experimental procedures described previously [23]. The purity of the compounds was checked by 1H and 13C NMR spectroscopy and LC-MS and were found to be >95% pure prior to biological experiments. NMR spectra were recorded on a Bruker 300 MHz spectrometer. LC-MS was carried out using the Acquity UPLC H-class system.
Pharmacology Priyanka Panwar, Kepa K. Burusco, Muna Abubaker, Holly Matthews, Andrey Gutnov, Elena Fernández-Álvaro, Richard A. Bryce, James Wilkinson, Niroshini Nirmalan DOI: 10.1128/AAC.01444-19 ABSTRACT Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel antimalarial treatments.
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