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Murphy R. Poplyk

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Articles by Murphy R. Poplyk

Purification processes of live virus vaccine candidates expressed in adherent Vero cell lines via multimodal chromatography in flowthrough mode

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By Spyridon Konstantinidis, Development Merck, Devan Reilly, Murphy R. Poplyk
| Wiley Online Library Verified
Impact of FN on Measles purification It was desired to understand the impact of FN on the purification train, and specifically the UF/DF step, during processing of Measles generated in the adherent Vero cell culture system. The ability of Capto MMC ImpRes to effectively remove FN allowed for the generation of a largely FN-free CP.
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Purification processes of live virus vaccine candidates expressed in adherent Vero cell lines via multimodal chromatography in flowthrough mode

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By Spyridon Konstantinidis, Development Merck, Murphy R. Poplyk, Devan Reilly
| Wiley Online Library Verified
1 INTRODUCTION The emergence of recombinant virus vectors as a platform for viral vaccines, due to the expression of heterologous viral proteins on their surface, has led to an increased focus on live virus vaccines (LVVs) (Travieso et al., 2022). Recently, a chimeric SARS-CoV-2 vaccine candidate, VSV∆G-SARS-CoV-2, was developed by replacing the live vesicular stomatitis virus glycoprotein gene with a coding sequence for the SARS-CoV-2 spike glycoprotein (Espeseth et al., 2022).
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