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Articles by Murray Epstein
Hyperkalemia with Mineralocorticoid Receptor Antagonist Use in People with CKD
aldosterone chronic kidney disease diabetic nephropathy hyperkalemia With the recent publication of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease (FIDELIO-DKD) (1) and the Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) (2) studies and with the recent approval of finerenone by the Food and Drug Administration (FDA) (3) and at least two other novel nonsteroidal mineralocorticoid receptor antagonists under...
Hyperkalemia with Mineralocorticoid Receptor Antagonist Use in People with CKD
aldosterone chronic kidney disease diabetic nephropathy hyperkalemia With the recent publication of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease (FIDELIO-DKD) (1) and the Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) (2) studies and with the recent approval of finerenone by the Food and Drug Administration (FDA) (3) and at least two other novel nonsteroidal mineralocorticoid receptor antagonists under...
The COVID-19 vaccine rollout: Lessons from the 1947 mass vaccination for Smallpox New York City
By : Murray Epstein In a February 2021 update Dr. Howard Zucker, the Commissioner of health of New York State, recalls a story of an earlier vaccination challenge that should inform on many levels. It recounts how the challenge of a small Smallpox outbreak in New York City in 1947 was met by an extraordinarily successful vaccination of the entire population of New York City (6,350,000 people) in a single month.
Renin-Angiotensin System Blockers and the COVID-19 Pandemic
Abstract During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19. This includes patients with hypertension, heart disease, diabetes mellitus, and clearly the elderly. Many of those patients are treated with reninangiotensin system blockers.
FDA removes boxed warning from Relypsa’s Veltassa - Nephrology News & Issues
FDA removes boxed warning from Relypsa’s Veltassa An updated label recommends patients take Veltassa at least three hours before or after other oral medications Getty Images/iStockphoto/ThinkStock The U.S. Food and Drug Administration has approved a supplemental New Drug Application for Relypsa Inc.’s Veltassa (patiromer), which removes the boxed warning regarding the separation of Veltassa and other oral medications from the label.
A propitious time for initiating clinical trials in patients with heart failure with reduced ejection fraction and an estimated glomerular filtration rate <30 mL/min with an mineralocorticoid receptor antagonist and a K+ binder: ‘the forbidden fruit’
Cardiovascular disease (CVD) remains the most common cause of premature death in the chronic kidney disease (CKD) population.1,2 Patients with CKD are at 10–20 times greater risk of cardiac death than controls without CKD, despite stratification for age, race, sex, and diabetes.
KDIGO launches redesigned guideline app
KDIGO launches redesigned guideline app Kidney Disease: Improving Global Outcomes (KDIGO) has launched a redesigned iOS and Android app. The new application, named KDIGO Mobile, offers a modern user interface and intuitive use experience, and provides unfettered access t th KDIGO library of clinical practice guidelines for nephrology, KDIGO said in a statement.
Auryxia production halt sends Keryx stock price plummeting
Getty Images/iStockphoto/ThinkStock The share price of dialysis drug maker Keryx Biopharmaceuticals went down almost 48% this week after the company announce it was temporarily halting manufacturing of its Auryxia oral phosphate binder due to production-related issues. The company stock price hit a year-high of $7.80 on Friday, having risen steadily since January. The announcement about interrupting production of Auryxia brought the stock price down to $4.17 on Tuesday.
CMO looks at ways to put meaning behind ‘quality care’
Getty Images/iStockphoto/ThinkStock Editor’s note: Fresenius Medical Care chief medical officer Frank Maddux, MD, recently authored a paper entitled, “Doing more than caring about quality” (Seminars in Dialysis March/April 2016). In an interview with NN&I, we ask him about points made in the paper and how he believes dialysis patient care can improve. This article is part of NN&I’s 22nd annual dialysis provider ranking.
Study associates Baxter’s Revaclear dialyzer with less need for ESAs during hemodialysis
Getty Images/iStockphoto/ThinkStock Baxter International Inc.’s Revaclear dialyzer was associated with lower use of erythropoiesis-stimulating agent, according to an observational cohort study published online in the American Society for Artificial Internal Organs Journal.
American Renal, Western Nephrology to open dialysis center in Colorado’s Vail Valley
American Renal, Western Nephrology to open dialysis center in Colorado’s Vail Valley American Renal Associates Holdings Inc., and Western Nephrology, one of the largest nephrology groups in Colorado, said they plan to open the Kidney Center of the Rockies in Avon, Colo. The outpatient dialysis facility is scheduled to open in the Fall of 2016. Patients will have multiple treatment options, including in-center hemodialysis, peritoneal dialysis and home hemodialysis.
Baxter dialysis sales up 2% in Q2
Getty Images/iStockphoto/ThinkStock Sales of dialysis products from Baxter International’s Renal division totaled $965 million in the second quarter, representing a 2% increase on a reported basis over last year, the company reported on July 26. Increased demand globally for continuous renal replacement therapies along with strong sales of peritoneal dialysis products contributed to growth in the quarter, the company said.
Empowering patients can improve the renal care experience - Nephrology News & Issues
Getty Images/iStockphoto/ThinkStock Last month I interviewed Francyne N. Rosenstock, vice president of Business Development and Marketing for Renal Reserve, about the causes of burnout among dialysis nurses. “I think nursing, in general, has a higher burnout rate than other disciplines in health care because nurses are on the front lines of patient care,” Rosenstock said. “They have a connection to their patients, especially patients who they are involved with over a long period of time.
Arrhythmias and sudden cardiac death in hemodialysis patients
Introduction Chronic kidney disease (CKD) affects more than 20 million people in the United States, approximately 1 in 15 American adults.
Nurse Licensure Compacts increase mobility for nurses
iStock photo psphotograph From 2000–2015, twenty-five states passed legislation to join the Nurse Licensure Compact (NLC, or Compact). The Compact license allows nurses (RNs and LPNs) whose primary state of residence is a compact state to practice in all other compact states whether that be physically, electronically or telephonically. For nurses who live in the current compact states, licenses automatically become multi-state licenses, as long as the nurse is in good standing.
Baxter appoints interim renal business president
Baxter appoints interim renal business president Getty Images/iStockphoto/ThinkStock</photocredit> Baxter International Inc.’s renal business president has left the company, Baxter announced. Giuseppe Accogli, former region head for Baxter’s U.S. renal business, assumed the role on May 3, 2016. The company said it is searching to permanently fill the role. “We would like to express our gratitude to Jill for her 15 years of service to Baxter,” said Baxter Chairman and CEO José (Joe) Almeida.
Study identifies factors influencing Vitamin D levels in kids with kidney disease
Study identifies factors influencing Vitamin D levels in kids with kidney disease A new study has found that Vitamin D levels in children with chronic kidney disease are influenced more strongly by seasonal factors, the type of disease and nutritional supplementation than by common variants in vitamin D regulating genes Getty Images/iStockphoto/ThinkStock A new study has found that Vitamin D levels in children with chronic kidney disease are influenced more strongly by seasonal factors, the...
Letter to the Editor: Reducing dialysis nurse burnout
Dear editor, I would like to take this opportunity to respond to the interview “Reducing Dialysis Nurse Burnout” (May 31, 2016) by Rebecca Zumoff. Despite being a factual interview that emphasizes many valid points, I believe the article overlooks a very important factor related to nephrology nurse burnout. This overlooked issue is the work burden on nephrology nurses due to challenges in recruiting novice nurses into the specialty.
AKF to study seeks to identify reasons for treatment non-adherence among kidney patients
Getty Images/iStockphoto/ThinkStock The American Kidney Fund (AKF) has launched a nationwide study examining the factors that can make it difficult for people who are on dialysis to adhere consistently to their prescribed treatment regimens. This study, funded by Amgen, seeks to identify reasons for non-adherence so that appropriate patient interventions may be designed.
Blood pressure medications reduce stroke and heart attack in peritoneal dialysis patients
Two classes of blood pressure medications, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), are associated with a 16% lower risk of strokes, heart attacks and death in patients with end-stage renal disease who are undergoing peritoneal dialysis, a new study in the journal, Nephrology Dialysis Transplantation, reports.
NKF collaborates with Johns Hopkins, Novartis to increase living kidney donation
NKF collaborates with Johns Hopkins, Novartis to increase living kidney donation Getty Images/iStockphoto/ThinkStock The National Kidney Foundation is collaborating with Johns Hopkins University and Novartis to launch the Live Donor Champion Program.
Clinical and electrophysiological consequences of hyperkalemia
Introduction Hyperkalemia is a common electrolyte disorder, especially among patients with chronic kidney disease (CKD), diabetes mellitus, or heart failure.1–3 Hyperkalemia represents one of the most important acute electrolyte abnormalities, due to its potential for causing life-threatening arrhythmias. Whereas hyperkalemia occurs relatively infrequently in individuals with normal kidney function, hyperkalemia can be much more common in patients who have predisposing conditions.
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