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Abstract Microbial constituents in the gastrointestinal tract, the urine and prostate tissue are being linked with clinical differences in prostate cancer, and a recent meta-analysis has linked periodontal disease to this cancer. Several hypotheses exist regarding how specific bacteria can contribute towards the development of prostate cancer.
Organotypic slice ovarian cancer model as a platform to test novel therapeutics A. Michael1, G. Falgari1, N. Annels1, P. Ellis2, W. Ashbourne2, S. Butler Manuel2 and H.S. Pandha1 1School of Biosciences and Medicine, Leggett Building, University of Surrey, Guildford, UK 2Gynaecological Oncology, Royal Surrey County Hospital, Guildford, UK Background: An effective way to test new drugs in a pre-clinical setting remains a challenging task.
Background: CAVATAK® is a novel, bio-selected Intercellular Adhesion Molecule 1 (ICAM-1) targeted immunotherapeutic Coxsackievirus A21 (CVA21). Surface ICAM-1 is up-regulated on NMIBC. CVA21 displays potent oncolytic activity against in vitro cultures of NMIBC cancer cells and ex-vivo human bladder tumor. Combining CVA21 with mitocycin C (MMC) synergistically enhances viral replication by increasing expression levels of ICAM-1.
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