Abstract To investigate the role of zebrafish zfpm2a in cardiac development and maintenance of cardiac function, and to explore its potential mechanisms in heart failure (HF). The evolutionary conservation of ZFPM2 and the spatiotemporal expression patterns of zebrafish zfpm2a were analyzed. A zfpm2a knockout zebrafish line (zfpm2a−/−) was generated to assess developmental and cardiac phenotypes. Cardiac tissue transcriptome sequencing was performed to identify pathways regulated by zfpm2a.
