The Data Science Lab Dr. James McCaffrey from Microsoft Research presents a complete end-to-end demo of Poisson regression, where the goal is to predict a count of things arriving, such as the number of telephone calls received in a 10-minute interval at a call center. When your source data is close to mathematically Poisson distributed, Poisson regression is simple and effective. The goal of a machine learning regression problem is to predict a single numeric value.