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Articles by Nan Che
Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy - Nature Communications
Abstract Minimally invasive thermal therapy is a successful alternative treatment to surgery in solid tumors with high complete ablation rates, however, tumor recurrence remains a concern. Central memory CD8+ T cells (TCM) play important roles in protection from chronic infection and cancer.
Coming of age: the formation and function of age-associated B cells - Cellular & Molecular Immunology
B cells are generated in the bone marrow during ontogeny and migrate to peripheral lymphoid organs, where they encounter antigens to elicit humoral immunity. During the past decade, many novel B-cell subsets with distinct phenotypes and functions have been identified, and among these subsets, age-associated B cells (ABCs) were first characterized as a B-cell subset that accumulates with age [1]. Emerging evidence has shown that ABCs are critically involved in various human diseases [2].
Case Report: Real NPSLE? A patient with systemic sclerosis overlapping systemic lupus erythematosus presenting as epilepsy
Highlights ● NPSLE is not the only answer to CNS symptoms in patients with SLE overlapping SSc. ● Distinguishing between RPLS due to SRC and NPSLE is critical for the patient’s prognosis. A 17-year-old female patient with a one-and-a-half-year history of SSc and SLE was admitted to our rheumatology department.
Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis - Nature Immunology
Abstract Appropriate regulation of B cell differentiation into plasma cells is essential for humoral immunity while preventing antibody-mediated autoimmunity; however, the underlying mechanisms, especially those with pathological consequences, remain unclear. Here, we found that the expression of Jmjd1c, a member of JmjC domain histone demethylase, in B cells but not in other immune cells, protected mice from rheumatoid arthritis (RA).
Correlation of peripheral CD4+GranzB+CTLs with disease severity in patients with primary Sjögren’s syndrome - Arthritis Research & Therapy
Research article Open Access Published: 12 October 2021 Qi Wang1, Nan Che1, Chengyin Lu1, Xiaoxuan Sun1, Yanyan Wang1, Qiang Wang1, Wenfeng Tan1, Lanlan Zhou1, Xiaojun Zhang1, Dong Xu2, Lei Gu ORCID: orcid.org/0000-0002-3254-91671 na1 & Miaojia Zhang1 na1 Arthritis Research & Therapy volume 23, Article number: 257 (2021) Cite this article Abstract Introduction Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease which has focal lymphocytic infiltration including a...
Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis
This study provides new evidence of the novel role of AD in bone erosion and the underlying mechanism of AD-mediated bone erosion in RA. Our most recent study demonstrated that AD correlates closely with progressive bone erosion in patients with RA [10] and that AD aggravates the process by enhancing the Th17 cell response and receptor activator of nuclear factor-?B ligand (RANKL) expression in CIA mice [11]. However, AD could inhibit osteoclast formation and differentiation [25, 26].
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