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Recent Advances in DNA-Encoded Libraries DNA-encoded library (DEL), a novel high-throughput screening platform that synergistically combines the strengths of combinatorial chemistry and genetic barcoding, has transitioned from a theoretical framework to a valuable technology within the pharmaceutical research landscape. As an emerging platform for drug discovery, DEL technology has undergone rapid evolution over the past thirty years.
To perform the activity-guided purification, the alkaloids enriched from S. tangutica using the SPE method19 were the first subject to separation on an XCharge C18 column. Results showed that the enriched alkaloids gave rises to a series of well separated and symmetric peaks even at an overloading amount on the column (Fig. 1a). Twenty-three fractions (F1 to F23) were collected sequentially according to visible peaks and these fractions have little peak overlapping (Fig. S1). Given that S.
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