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Systemic chemotherapy can result in considerable reduction of the size of colorectal liver metastases (CRLMs) to the point where they sometimes decrease even below the resolution of imaging modalities. These ‘vanishing lesions’ are observed in approximately 20% of patients, even with state-of-the-art imaging1. Nonetheless, microscopic residual disease is frequently present2,3 and tumour regrowth occurs in approximately one-third after ‘watch and wait’1.
D. Wasserberg, J. Cabanas-Danes, V. Subramaniam, J. Huskens and P. Jonkheijm, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C7CC09808A If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
The ability of HIV-1 to replicate and to establish long-term reservoirs is strongly influenced by T cell activation. Through the use of membrane-tethered, genetically encoded calcium (Ca2+) indicators, we were able to detect for the first time, to our knowledge, the formation of Ca2+ territories and determine their role in coordinating the functional signaling nanostructure of the synaptic membrane.
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