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Articles by Nataly Kacherovsky
Discovery and Cryo-EM-Guided Development of a Neuropilin-2-Binding Aptamer for Receptor Antagonism Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Receptor antagonists represent a major class of targeted cancer therapeutics, yet SELEX-based aptamer discovery often yields high-affinity binders that display limited functional blockade because epitope positioning is not explicitly selected.
Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations
Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations Aptamers are single-stranded nucleic acids that bind and recognize targets much like antibodies. Recently, aptamers have garnered increased interest due to their unique properties, including inexpensive production, simple chemical modification, and long-term stability. At the same time, aptamers possess similar binding affinity and specificity as their protein counterpart.
Discovery and Characterization of Spike N‐Terminal Domain‐Binding Aptamers for Rapid SARS‐CoV‐2 Detection
Abstract The coronavirus disease 2019 (COVID-19) pandemic has devastated families and disrupted healthcare, economies and societies across the globe. Molecular recognition agents that are specific for distinct viral proteins are critical components for rapid diagnostics and targeted therapeutics. In this work, we demonstrate the selection of novel DNA aptamers that bind to the SARS-CoV-2 spike glycoprotein with high specificity and affinity (<80 nM).
Traceless aptamer-mediated isolation of CD8+ T cells for chimeric antigen receptor T-cell therapy
Abstract Chimeric antigen receptor T-cell therapies using defined product compositions require high-purity T-cell isolation systems that, unlike immunomagnetic positive enrichment, are inexpensive and leave no trace on the final cell product. Here, we show that DNA aptamers (generated with a modified cell−SELEX procedure to display low-nanomolar affinity for the T-cell marker CD8) enable the traceless isolation of pure CD8+ T cells at low cost and high yield.
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