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Articles by Natalya Wells
Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development
DMEM Dulbecco's Modified Eagle Medium GGPS1 geranylgeranyl diphosphate synthase1 HMGCR 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase HMGCS1 3-hydroxy-3-methyl-glutaryl-coenzyme A synthase1 HTSeq high throughput sequence analysis KEGG Kyoto Encyclopedia of Genes and Genomes LGMD limb-girdle muscular dystrophy MHC myosin heavy chain MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Myod myogenic differentiation 1 Myog myogenin OCR oxygen consumption rate qPCR quantitative...
Effects of HMGCR deficiency on skeletal muscle development
Abstract Pathogenic variants in HMGCR were recently linked to a limb-girdle muscular dystrophy (LGMD) phenotype. The protein product HMG CoA reductase (HMGCR) catalyzes a key component of the cholesterol synthesis pathway. The two other muscle diseases associated with HMGCR, statin-associated myopathy (SAM) and autoimmune anti-HMGCR myopathy, are not inherited in a Mendelian pattern. The mechanism linking pathogenic variants in HMGCR with skeletal muscle dysfunction is unclear.
Conflict in Nigeria: Why Access to Health Care is a Luxury Few Can Afford - Australian Institute of International Affairs
For Australians, it might be difficult to imagine a scenario where there are no hospitals to walk into or no medical personnel to consult about the most basic of health issues. But this is the reality for thousands of people affected by the ongoing armed conflict in northeastern Nigeria. The conflict, which began in 2009 in the state of Borno, escalated rapidly, engulfing the neighboring states of Adamawa and Yobe before fanning out to the neighboring countries of Chad, Niger and Cameroon.
Eastern Ghouta: Damned and Desperate - AIIA
On the outskirts of Damascus, in Eastern Ghouta, nearly half a million Syrians continue to suffer indiscriminate bombing and inadequate provision for humanitarian assistance. And the situation is only expected to get worse. The human suffering in Eastern Ghouta, Syria is a consequence of a conflict without restraint. There are approximately 400,000 people, under enormous pressure.
Challenges on the Move: Going Missing - AIIA
With the global number of displaced people at a record high, refugee families are as vulnerable to separation as ever. To mitigate this, the International Committee of the Red Cross is taking innovative steps to help engineer reunifications. Just before Christmas, Clementina Murcia was reunited with her missing son Mauro, 16 long years after he migrated from Honduras to Mexico.
The world’s first Humanitarian Impact Bond - Devpolicy Blog from the Development Policy Centre
Around the world, humanitarian organisations are struggling to meet growing needs with dwindling funds and are seeking innovative ways to source funding. The International Committee of the Red Cross (ICRC), with some far-sighted partners and intrepid investors, is testing out the success – or otherwise – of a new funding mechanism.
Nuclear Weapons and the Future of Humanity
Global discussion on nuclear weapons has evolved from debating their role in military and security strategy to understanding the humanitarian consequences of their use. The International Committee of the Red Cross (ICRC) welcomes this shift in focus, which enables policymakers to better consider and weigh the human cost of potential nuclear weapon use against its strategic value.
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